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dc.contributor.author
Veuthey, Tania Vanesa
dc.contributor.author
Hoffmann, Dana
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Vaidya, Vishal S.
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Wessling Resnick, Marianne
dc.date.available
2017-12-14T17:43:20Z
dc.date.issued
2014-02
dc.identifier.citation
Veuthey, Tania Vanesa; Hoffmann, Dana; Vaidya, Vishal S.; Wessling Resnick, Marianne; Impaired renal function and development in Belgrade rats; American Physiological Society; American Journal Of Physiology-renal Physiology; 306; 3; 2-2014; 333-343
dc.identifier.issn
1931-857X
dc.identifier.uri
http://hdl.handle.net/11336/30641
dc.description.abstract
Belgrade rats carry a disabling mutation in the iron transporter divalent metal transporter 1 (DMT1). Although DMT1 plays a major role in intestinal iron absorption, the transporter is also highly expressed in the kidney, where its function remains unknown. The goal of this study was to characterize renal physiology of Belgrade rats. Male Belgrade rats died prematurely with ∼50% survival at 20 wk of age. Necropsy results indicated marked glomerular nephritis and chronic end-stage renal disease. By 15 wk of age, Belgrade rats displayed altered renal morphology associated with sclerosis and fibrosis. Creatinine clearance was significantly lower compared with heterozygote littermates. Urinary biomarkers of kidney injury, including albumin, fibrinogen, and kidney injury molecule-1, were significantly elevated. Pilot morphological studies suggest that nephrogenesis is delayed in Belgrade rat pups due to their low iron status and fetal growth restriction. Such defects in renal development most likely underlie the compromised renal metabolism observed in adult b/b rats. Belgrade rat kidney nonheme iron levels were not different from controls but urinary iron and transferrin levels were higher. These results further implicate an important role for the transporter in kidney function not only in iron reabsorption but also in glomerular filtration of the serum protein.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Physiological Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dmt1
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Kidney
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Iron Deficiency Anemia
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Renal Developmentt
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Impaired renal function and development in Belgrade rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-12T18:42:28Z
dc.journal.volume
306
dc.journal.number
3
dc.journal.pagination
333-343
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Veuthey, Tania Vanesa. Harvard University. Harvard School of Public Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Hoffmann, Dana. Harvard University. Harvard School of Public Health; Estados Unidos
dc.description.fil
Fil: Vaidya, Vishal S.. Harvard University. Harvard School of Public Health; Estados Unidos
dc.description.fil
Fil: Wessling Resnick, Marianne. Harvard University. Harvard School of Public Health; Estados Unidos
dc.journal.title
American Journal Of Physiology-renal Physiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1152/ajprenal.00285.2013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.physiology.org/doi/full/10.1152/ajprenal.00285.2013
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