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dc.contributor.author
Gomez, María Lorena
dc.contributor.author
Gallastegui, Antonela
dc.contributor.author
Spesia, Mariana Belen
dc.contributor.author
Montejano, Hernan Alfredo
dc.contributor.author
Williams, Roberto Juan Jose
dc.contributor.author
Previtali, Carlos Mario
dc.date.available
2017-12-14T17:21:42Z
dc.date.issued
2016-09-13
dc.identifier.citation
Gomez, María Lorena; Gallastegui, Antonela; Spesia, Mariana Belen; Montejano, Hernan Alfredo; Williams, Roberto Juan Jose; et al.; Synthesis of poly(HEMA-co-AAm) hydrogels by visible-light photopolymerization of aqueous solutions containing aspirin or ibuprofen: analysis of the initiation mechanism and the drug release; John Wiley & Sons Ltd; Polymers For Advanced Technologies; 28; 4; 13-9-2016; 435-442
dc.identifier.issn
1042-7147
dc.identifier.uri
http://hdl.handle.net/11336/30623
dc.description.abstract
Recently, we reported the synthesis of hydrogels by visible-light photopolymerization of 2-hydroxyethylmethacrylate and acrylamide, employing safranine O as sensitizer, and a functionalized silsequioxane (SFMA) as co-initiator/crosslinker. The influence of the ionic character of a drug on its release rate from the hydrogels was also reported. In the present study, we analyzed the photoinitiation mechanism, the synthesis of hydrogels in the presence of aspirin (ASA) or ibuprofen (Ibu), and their release from hydrogels synthesized with variable SFMA concentrations. Concerning the photoinitiation mechanism, we found that the main contribution was the electron transfer reaction between the excited triplet state of safranine and SFMA, followed by a fast proton transfer reaction from secondary amine groups. The generated nitrogen radicals initiated the copolymerization reaction. The photoreaction quantum yield was 0.031. Concerning the drug-release study, we found that the release rate of both drugs increased by increasing pH from 7 to 10. This was ascribed to the increase in the partial ionization of the carboxylic acid groups, a fact that reduced the interactions with the secondary amine groups present in SFMA and increased the release rate. The effect was larger for ASA than for Ibu. Increasing the amount of SFMA increased both the crosslink density and the fraction of H-bonds formed with the drugs. At pH 10, the increment in the crosslink density was dominant for the release of Ibu while the increase in fraction of H-bonds determined the release rate of ASA. Cytotoxicity studies showed that these materials did not exhibit significant hemolytic activity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hydrogels
dc.subject
Silsesquioxane
dc.subject
Photopolymerization
dc.subject
Aspirin
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Ibuprofen
dc.subject.classification
Recubrimientos y Películas
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Ingeniería de los Materiales
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Synthesis of poly(HEMA-co-AAm) hydrogels by visible-light photopolymerization of aqueous solutions containing aspirin or ibuprofen: analysis of the initiation mechanism and the drug release
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-04T18:04:21Z
dc.journal.volume
28
dc.journal.number
4
dc.journal.pagination
435-442
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Gomez, María Lorena. Universidad Nacional de Río Cuarto; Argentina
dc.description.fil
Fil: Gallastegui, Antonela. Universidad Nacional de Río Cuarto; Argentina
dc.description.fil
Fil: Spesia, Mariana Belen. Universidad Nacional de Río Cuarto; Argentina
dc.description.fil
Fil: Montejano, Hernan Alfredo. Universidad Nacional de Río Cuarto; Argentina
dc.description.fil
Fil: Williams, Roberto Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: Previtali, Carlos Mario. Universidad Nacional de Río Cuarto; Argentina
dc.journal.title
Polymers For Advanced Technologies
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/pat.3958
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/pat.3958/abstract
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