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Artículo

Chlorpyrifos inhibits cell proliferation through ERK1/2 phosphorylation in breast cancer cell lines

Ventura, ClaraIcon ; Venturino, AndresIcon ; Miret, Noelia VictoriaIcon ; Randi, Andrea SilvanaIcon ; Rivera, Elena Susana; Nuñez, Mariel; Cocca, Claudia MarcelaIcon
Fecha de publicación: 08/2014
Editorial: Elsevier
Revista: Chemosphere
ISSN: 0045-6535
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias de la Salud

Resumen

It is well known the participation of oxidative stress in the induction and development of different pathologies including cancer, diabetes, neurodegeneration and respiratory disorders among others. It has been reported that oxidative stress may be induced by pesticides and it could be the cause of health alteration mediated by pollutants exposure. Large number of registered products containing chlorpyrifos (CPF) is used to control pest worldwide. We have previously reported that 50 μM CPF induces ROS generation and produces cell cycle arrest followed by cell death. The present investigation was designed to identify the pathway involved in CPF-inhibited cell proliferation in MCF-7 and MDA-MB-231 breast cancer cell lines. In addition, we determined if CPF-induced oxidative stress is related to alterations in antioxidant defense system. Finally we studied the molecular mechanisms underlying in the cell proliferation inhibition produced by the pesticide. In this study we demonstrate that CPF (50 μM) induces redox imbalance altering the antioxidant defense system in breast cancer cells. Furthermore, we found that the main mechanism involved in the inhibition of cell proliferation induced by CPF is an increment of p-ERK1/2 levels mediated by H2O2 in breast cancer cells. As PD98059 could not abolish the increment of ROS induced by CPF, we concluded that ERK1/2 phosphorylation is subsequent to ROS production induced by CPF but not the inverse.
Palabras clave: Organophosphorus , Chlorpyrifos , Breast Cancer Cell Lines , Erk1/2
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/30543
DOI: http://dx.doi.org/10.1016/j.chemosphere.2014.07.088
URL: https://www.sciencedirect.com/science/article/pii/S0045653514009631
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Articulos(CCT - PATAGONIA NORTE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - PATAGONIA NORTE
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Ventura, Clara; Venturino, Andres; Miret, Noelia Victoria; Randi, Andrea Silvana; Rivera, Elena Susana; et al.; Chlorpyrifos inhibits cell proliferation through ERK1/2 phosphorylation in breast cancer cell lines; Elsevier; Chemosphere; 120; 8-2014; 343-350
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