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dc.contributor.author
Martinel Lamas, Diego José
dc.contributor.author
Rivera, Elena Susana
dc.contributor.author
Medina, Vanina Araceli
dc.date.available
2017-12-13T21:40:53Z
dc.date.issued
2014-06
dc.identifier.citation
Martinel Lamas, Diego José; Rivera, Elena Susana; Medina, Vanina Araceli; Histamine H4 receptor: insights into a potential therapeutic target in breast cancer; Frontiers in Bioscience; Frontiers in Bioscience; 7; 6-2014; 1-9
dc.identifier.issn
1093-9946
dc.identifier.uri
http://hdl.handle.net/11336/30537
dc.description.abstract
Breast cancer is the second most common cancer worldwide, and the leading cause of cancer death in women. Several studies underlined the critical role of histamine in breast cancer development and progression. This review addresses the latest evidence regarding the involvement of histamine and histamine receptors in breast cancer, focusing particularly in the histamine H4 receptor (H4R). Histamine concentration in breast cancer tissues was found to be higher than that in normal tissues of healthy controls by means of an increase in the activity of histidine decarboxylase (HDC), the enzyme involved in histamine production. The expression of H4R in different experimental models and human biopsies, the associated biological responses, as well as the in vivo treatment of experimental tumors with H4R ligands is reviewed. Evidence demonstrates that the H4R exhibits a key role in histamine-mediated biological processes such as cell proliferation, senescence and apoptosis in breast cancer. The polymorphisms of the H4R and HDC genes and their association with breast cancer risk and malignancy reinforce the critical (patho)physiological role of H4R in breast cancer. In addition, H4R agonists display anti-tumor effects in vivo in a triple negative breast cancer model. The findings support the exploitation of the H4R as a molecular target for breast cancer drug development.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers in Bioscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Histamine
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Histamine H4 Receptor
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Proliferation
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H4r Ligands
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Histamine H4 receptor: insights into a potential therapeutic target in breast cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-12T18:30:01Z
dc.journal.volume
7
dc.journal.pagination
1-9
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Martinel Lamas, Diego José. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisotopos; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Rivera, Elena Susana. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisotopos; Argentina
dc.description.fil
Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisotopos; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.journal.title
Frontiers in Bioscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2741/420
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.bioscience.org/2015/v7s/af/420/list.htm
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