Artículo
Flavonoids from Pterocaulon alopecuroides with antibacterial activity
Alarcón, Silvia Rosana; Carrizo Flores, Roberto Ascencio
; Ocampos, Soledad; Lucatti, Alejandro Francisco
; Flores Galleguillo, Laura; Tonn, Carlos Eugenio
; Sosa, Virginia Estela
Fecha de publicación:
10/2008
Editorial:
Georg Thieme Verlag Kg
Revista:
Planta Medica
ISSN:
0032-0943
e-ISSN:
1439-0221
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Three flavonoids, (2R,3R)-5,4′-dihydroxy-3′-O-methyl-7-(γ,γ-dimethylallyloxy)dihydroflavonol 1, (2R,3R)-5,7,4′-trihydroxy-3′-O-methyl-6-(α,α-dimethylallyl)dihydroflavonol 2, and (2R,3R)-5,7,4′-trihydroxy-6-(α,α-dimethylallyl)dihydroflavonol 3, together with three known flavonoids (4 – 6), were isolated from the aerial parts of Pterocaulon alopecuroides. The structures of the compounds were determined by mass and by 1 D and 2 D NMR spectroscopy. Screening of the antibacterial activity of all six compounds was conducted by a disc diffusion test against Bacillus cereus, Bacillus subtilis, Salmonella typhimurium and Proteus mirabilis. The minimum inhibitory concentration (MIC) of the active compounds (2, 3, 4, 6) was determined by a microdilution assay. These compounds were active only against both Gram (+) bacteria with MIC values ≤ 200 μg/mL.
Palabras clave:
Pterocaulon Alopecuroides
,
Asteraceae
,
Flavonoids
,
Antibacterial Activity
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Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Citación
Alarcón, Silvia Rosana; Carrizo Flores, Roberto Ascencio; Ocampos, Soledad; Lucatti, Alejandro Francisco; Flores Galleguillo, Laura; et al.; Flavonoids from Pterocaulon alopecuroides with antibacterial activity; Georg Thieme Verlag Kg; Planta Medica; 74; 12; 10-2008; 1463-1467
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