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dc.contributor.author
Pautasso, María Constanza
dc.contributor.author
Rossi, Silvia Graciela
dc.date.available
2017-12-13T18:07:03Z
dc.date.issued
2014-04
dc.identifier.citation
Pautasso, María Constanza; Rossi, Silvia Graciela; Transcriptional regulation of the protein kinase A subunits in Saccharomyces cerevisiae: autoregulatory role of the kinase A activity; Elsevier Science; Biochimica Et Biophysica Acta-gene Regulatory Mechanisms; 1839; 4; 4-2014; 275-287
dc.identifier.issn
1874-9399
dc.identifier.uri
http://hdl.handle.net/11336/30478
dc.description.abstract
Protein kinase A (PKA) is a broad specificity protein kinase that controls a physiological response following the increment of cAMP as a consequence of a particular stimulus. The specificity of cAMP-signal transduction is maintained by several levels of control acting all together. Herein we present the study of the regulation of the expression of each PKA subunit, analyzing the activity of their promoters. The promoter of each isoform of TPK and of BCY1 is differentially activated during the growth phase. A negative mechanism of isoform-dependent autoregulation directs TPKs and BCY1 gene expressions. TPK1 promoter activity is positively regulated during heat shock and saline stress. The kinase Rim15, but not the kinase Yak1, positively regulates TPK1 promoter. Msn2/4, Gis1, and Sok2 are transcription factors involved in the regulation of TPK1 expression during stress. TPK2, TPK3, and BCY1 promoters, unlike TPK1, are not activated under stress conditions, although all the promoters are activated under low or null protein kinase A activity. These results indicate that subunits share an inhibitory autoregulatory mechanism but have different mechanisms involved in response to heat shock or saline stress.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Pka
dc.subject
Transcription Regulation
dc.subject
Tpks
dc.subject
Bcy1
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Transcriptional regulation of the protein kinase A subunits in Saccharomyces cerevisiae: autoregulatory role of the kinase A activity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-12T18:49:35Z
dc.journal.volume
1839
dc.journal.number
4
dc.journal.pagination
275-287
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Pautasso, María Constanza. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rossi, Silvia Graciela. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Biochimica Et Biophysica Acta-gene Regulatory Mechanisms
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbagrm.2014.02.005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1874939914000261


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