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dc.contributor.author Agotegaray, Mariela Alejandra
dc.contributor.author Gumilar, Fernanda Andrea
dc.contributor.author Boeris, Monica
dc.contributor.author Toso, Ricardo Enrique
dc.contributor.author Minetti, Silvia Alejandra
dc.date.available 2017-12-13T17:01:41Z
dc.date.issued 2014-07
dc.identifier.citation Agotegaray, Mariela Alejandra; Gumilar, Fernanda Andrea; Boeris, Monica; Toso, Ricardo Enrique; Minetti, Silvia Alejandra; Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug: Promising Insights in the Treatment of Chronic Inflammatory Diseases; Hindawi Publishing Corporation; Biomedical Research International; 2014; 7-2014; 1-9; 505987
dc.identifier.issn 2314-6133
dc.identifier.uri http://hdl.handle.net/11336/30455
dc.description.abstract Analgesic and ulcerogenic properties have been studied for the copper(II) coordination complex of the nonsteroidal anti-inflammatory drug Fenoprofen and imidazole [Cu(fen)2(im)2] (Cu: copper(II) ion; fen: fenoprofenate anion from Fenoprofen, im: imidazole). A therapeutic dose of 28 mg/kg was tested for [Cu(fen)2(im)2] and 21 mg/kg was employed for Fenoprofen calcium, administered by oral gavage in female mice to compare the therapeutic properties of the new entity. The acetic acid induced writhing test was employed to study visceral pain. The percentage of inhibition in writhing and stretching was 78.9% and 46.2% for the [Cu(fen)2(im)2] and Fenoprofen calcium, respectively. This result indicates that the complex could be more effective in diminishing visceral pain. The formalin test was evaluated to study the impact of the drugs over nociceptive and inflammatory pain. The complex is a more potent analgesic on inflammatory pain than the parent drug. Ulcerogenic effects were evaluated using a model of gastric lesions induced by hypothermic-restraint stress. Fenoprofen calcium salt caused an ulcer index of about 79 mm2 while the one caused by [Cu(fen)2(im)2] was 22 mm2. The complex diminished the development of gastric mucosal ulcers in comparison to the uncomplexed drug. Possible mechanisms of action related to both therapeutic properties have been discussed.
dc.format application/pdf
dc.language.iso eng
dc.publisher Hindawi Publishing Corporation
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject COMPLEJOS ANTIINFLAMATORIOS Cu
dc.subject ANTIINFLAMATORIOS NO ESTEROIDALES
dc.subject EFECTO ANTINOCICEPTIVO
dc.subject EFECTO ANTIINFLAMATORIO
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug: Promising Insights in the Treatment of Chronic Inflammatory Diseases
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-12-12T18:45:10Z
dc.identifier.eissn 2314-6141
dc.journal.volume 2014
dc.journal.pagination 1-9; 505987
dc.journal.pais Egipto
dc.journal.ciudad El Cairo
dc.description.fil Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil Fil: Gumilar, Fernanda Andrea. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Boeris, Monica. Universidad Nacional de la Pampa. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil Fil: Toso, Ricardo Enrique. Universidad Nacional de la Pampa. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil Fil: Minetti, Silvia Alejandra. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title Biomedical Research International
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2014/505987
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2014/505987/


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)