Mostrar el registro sencillo del ítem

dc.contributor.author
Agotegaray, Mariela Alejandra
dc.contributor.author
Gumilar, Fernanda Andrea
dc.contributor.author
Boeris, Monica
dc.contributor.author
Toso, Ricardo Enrique
dc.contributor.author
Minetti, Silvia Alejandra
dc.date.available
2017-12-13T17:01:41Z
dc.date.issued
2014-07
dc.identifier.citation
Agotegaray, Mariela Alejandra; Gumilar, Fernanda Andrea; Boeris, Monica; Toso, Ricardo Enrique; Minetti, Silvia Alejandra; Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug: Promising Insights in the Treatment of Chronic Inflammatory Diseases; Hindawi Publishing Corporation; Biomedical Research International; 2014; 7-2014; 1-9; 505987
dc.identifier.issn
2314-6133
dc.identifier.uri
http://hdl.handle.net/11336/30455
dc.description.abstract
Analgesic and ulcerogenic properties have been studied for the copper(II) coordination complex of the nonsteroidal anti-inflammatory drug Fenoprofen and imidazole [Cu(fen)2(im)2] (Cu: copper(II) ion; fen: fenoprofenate anion from Fenoprofen, im: imidazole). A therapeutic dose of 28 mg/kg was tested for [Cu(fen)2(im)2] and 21 mg/kg was employed for Fenoprofen calcium, administered by oral gavage in female mice to compare the therapeutic properties of the new entity. The acetic acid induced writhing test was employed to study visceral pain. The percentage of inhibition in writhing and stretching was 78.9% and 46.2% for the [Cu(fen)2(im)2] and Fenoprofen calcium, respectively. This result indicates that the complex could be more effective in diminishing visceral pain. The formalin test was evaluated to study the impact of the drugs over nociceptive and inflammatory pain. The complex is a more potent analgesic on inflammatory pain than the parent drug. Ulcerogenic effects were evaluated using a model of gastric lesions induced by hypothermic-restraint stress. Fenoprofen calcium salt caused an ulcer index of about 79 mm2 while the one caused by [Cu(fen)2(im)2] was 22 mm2. The complex diminished the development of gastric mucosal ulcers in comparison to the uncomplexed drug. Possible mechanisms of action related to both therapeutic properties have been discussed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Complejos Antiinflamatorios Cu
dc.subject
Antiinflamatorios No Esteroidales
dc.subject
Efecto Antinociceptivo
dc.subject
Efecto Antiinflamatorio
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug: Promising Insights in the Treatment of Chronic Inflammatory Diseases
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-12T18:45:10Z
dc.identifier.eissn
2314-6141
dc.journal.volume
2014
dc.journal.pagination
1-9; 505987
dc.journal.pais
Egipto
dc.journal.ciudad
El Cairo
dc.description.fil
Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Gumilar, Fernanda Andrea. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Boeris, Monica. Universidad Nacional de la Pampa. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Toso, Ricardo Enrique. Universidad Nacional de la Pampa. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Minetti, Silvia Alejandra. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Biomedical Research International
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2014/505987
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2014/505987/


Archivos asociados

 

Comunidades y colecciones

Mostrar el registro sencillo del ítem