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dc.contributor.author
Veuthey, Tania Vanesa  
dc.contributor.author
Wessling Resnick, Marianne  
dc.date.available
2017-12-12T19:43:44Z  
dc.date.issued
2014-04  
dc.identifier.citation
Veuthey, Tania Vanesa; Wessling Resnick, Marianne; Pathophysiology of the Belgrade rat; Frontiers; Frontiers in Pharmacology; 5; 4-2014; 1-13; 82  
dc.identifier.uri
http://hdl.handle.net/11336/30341  
dc.description.abstract
The Belgrade rat is an animal model of divalent metal transporter 1 (DMT1) deficiency. This strain originates from an X-irradiation experiment first reported in 1966. Since then, the Belgrade rat’s pathophysiology has helped to reveal the importance of iron balance and the role of DMT1. This review discusses our current understanding of iron transport homeostasis and summarizes molecular details of DMT1 function. We describe how studies of the Belgrade rat have revealed key roles for DMT1 in iron distribution to red blood cells as well as duodenal iron absorption. The Belgrade rat’s pathology has extended our knowledge of hepatic iron handling, pulmonary and olfactory iron transport as well as brain iron uptake and renal iron handling. For example, relationships between iron and manganese metabolism have been discerned since both are essential metals transported by DMT1. Pathophysiologic features of the Belgrade rat provide us with a unique and interesting animal model to understand iron homeostasis.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Belgrade Rat  
dc.subject
Slc11a2  
dc.subject
Dmt1  
dc.subject
Iron  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Pathophysiology of the Belgrade rat  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-12-12T18:42:24Z  
dc.identifier.eissn
1663-9812  
dc.journal.volume
5  
dc.journal.pagination
1-13; 82  
dc.journal.pais
Suiza  
dc.description.fil
Fil: Veuthey, Tania Vanesa. Harvard University. Harvard School of Public Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Wessling Resnick, Marianne. Harvard University. Harvard School of Public Health; Estados Unidos  
dc.journal.title
Frontiers in Pharmacology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fphar.2014.00082  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphar.2014.00082/full