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dc.contributor.author
Brance, María Lorena
dc.contributor.author
Brun, Lucas Ricardo Martín
dc.contributor.author
Di Loreto, Verónica Elina
dc.contributor.author
Lupo, Maela
dc.contributor.author
Rigalli, Alfredo
dc.date.available
2017-12-12T14:40:36Z
dc.date.issued
2014-08
dc.identifier.citation
Brance, María Lorena; Brun, Lucas Ricardo Martín; Di Loreto, Verónica Elina; Lupo, Maela; Rigalli, Alfredo; Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats; Taylor & Francis Ltd; Climacteric; 17; 4; 8-2014; 478-485
dc.identifier.issn
1369-7137
dc.identifier.uri
http://hdl.handle.net/11336/30250
dc.description.abstract
Objective Osteoporosis is the consequence of an imbalance in bone remodeling caused by excessive resorption or inappropriate bone formation. This paper proposes a sequential treatment with monofl uorophosphate (MFP) and zoledronic acid (Z), together with changes in the calcium content in the diet. Method Seven-week-old female Sprague Dawley rats were divided into fi ve groups ( n 21 per group): (1) sham-operated rats (Sham); (2) ovariectomized (OVX) rats fed with a normal calcium diet (OVX); (3) OVX rats fed with a normal calcium diet and treated sequentially with monofl uorophosphate and zoledronic acid (OVX.G1); (4) OVX rats sequentially fed with a low calcium diet and then a high calcium diet, without treatment (OVX.G2); (5): OVX rats fed with a low calcium diet and then a high calcium diet, treated sequentially with monofl uorophosphate and zoledronic acid (OVX.G3). Results After 150 days, the OVX.G3 group showed a similar bone volume to that of the Sham group due to an increase in trabecular number. Dual X-ray absorptiometry bone analysis showed an increase of 9.8% compared with OVX rats. Additionally, an increase in the fracture load at the cortical bone and higher fracture load, ultimate load and stiffness in the compression test were found. Conclusion The sequential treatment with monofl uorophosphate and zoledronic acid increases trabecular bone mass, bone mineral density and bone strength.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Monofluorophosphate
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Zoledronic Acid
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Osteoporosis
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Bone Mass
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Bone Strength
dc.subject.classification
Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-11T14:57:16Z
dc.identifier.eissn
1473-0804
dc.journal.volume
17
dc.journal.number
4
dc.journal.pagination
478-485
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Brance, María Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Brun, Lucas Ricardo Martín. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
dc.description.fil
Fil: Di Loreto, Verónica Elina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
dc.description.fil
Fil: Lupo, Maela. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Consejo de Investigación; Argentina
dc.journal.title
Climacteric
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/13697137.2013.860117
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/13697137.2013.860117
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