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dc.contributor.author
Quarleri, Jorge Fabian
dc.date.available
2017-12-11T22:52:38Z
dc.date.issued
2014-01
dc.identifier.citation
Quarleri, Jorge Fabian; Core promoter: A critical region where the hepatitis B virus makes decisions; Baishideng Publishing Group; World Journal of Gastroenterology; 20; 2; 1-2014; 425-435
dc.identifier.issn
1007-9327
dc.identifier.uri
http://hdl.handle.net/11336/30230
dc.description.abstract
The core promoter (CP) of the viral genome plays an important role for hepatitis B virus (HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic (pg) RNAs. The CP consists of the upper regulatory region and the basal core promoter (BCP). The CP overlaps with the 3’-end of the X open reading frames and the 5’-end of the precore region, and contains cis-acting elements that can independently direct transcription of the precore mRNA and pgRNA. Its transcription regulation is under strict control of viral and cellular factors. Even though this regulatory region exhibits high sequence conservation, when variations appear, they may contribute to the persistence of HBV within the host, leading to chronic infection and cirrhosis, and eventually, hepatocellular carcinoma. Among CP sequence variations, those occurring at BCP may dysregulate viral gene expression with emphasis in the hepatitis B e antigen, and contribute to disease progression. In this review these molecular aspects and pathologic topics of core promoter are deeply evaluated.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Baishideng Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Hepatitis B Virus
dc.subject
Core Promoter
dc.subject
Variants
dc.subject
Basal Core Promoter
dc.subject
Transcription Regulation
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Core promoter: A critical region where the hepatitis B virus makes decisions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-11T16:43:11Z
dc.identifier.eissn
2219-2840
dc.journal.volume
20
dc.journal.number
2
dc.journal.pagination
425-435
dc.journal.pais
China
dc.journal.ciudad
Beijing
dc.description.fil
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.journal.title
World Journal of Gastroenterology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923017/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v20/i2/425.htm
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3748/wjg.v20.i2.425


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  • Articulos(INBIRS) [116]
    Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA

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