Artículo
Use of the polymerase-chain reaction (PCR) for early evaluation of etiological treatment in young adults chronically infected with Trypanosoma cruzi
Lacunza, Carlos Diego; Sánchez Negrette, Olga; Mora, Maria Celia
; Uncos, Delfor Alejandro
; Segura, Maria Asuncion; del Castillo, Nestor Sigfrido
; Garayzabal, María Isabel
; Basombrio, Miguel Angel Manuel
Fecha de publicación:
26/12/2006
Editorial:
Universidade Federal de Goiás
Revista:
Revista de Patologia Tropical
ISSN:
0301-0406
e-ISSN:
1980-8178
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Fourteen patients (age limits: 18-30) chronically infected with Trypanosoma cruzi and presenting positive blood PCR reactions, were submitted to etiological treatment with benznidazole, in Salta, Argentina. A control group of five patients of the same age and positive by PCR did not receive treatment. Post-treatment follow-up was performed with PCR and conventional serology. PCR became negative in 12/14 (85.7%) of the treated patients after six months follow up, compared to 1/5 (20%) in the control group (p = 0.01). All patients remained serologically positive after treatment.The reduction of PCR signals of infection after treatment may become an early evidence of cure in chronically infected young adult patients.
Palabras clave:
Chagas Disease
,
Etiological Treatment
,
Pcr
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Articulos(IPE)
Articulos de INST.DE PATOLOGIA EXPERIMENTAL
Articulos de INST.DE PATOLOGIA EXPERIMENTAL
Citación
Lacunza, Carlos Diego; Sánchez Negrette, Olga; Mora, Maria Celia; Uncos, Delfor Alejandro; Segura, Maria Asuncion; et al.; Use of the polymerase-chain reaction (PCR) for early evaluation of etiological treatment in young adults chronically infected with Trypanosoma cruzi; Universidade Federal de Goiás; Revista de Patologia Tropical; 35; 3; 26-12-2006; 217-232
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