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dc.contributor.author
Ramirez, Juan
dc.contributor.author
Rodriguez, Maria Victoria
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Quiroga, Jairo
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Abonia, Rodrigo
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Sortino, Maximiliano Andrés
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Zacchino, Susana Alicia Stella
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Insuasty, Braulio
dc.date.available
2017-12-07T17:14:44Z
dc.date.issued
2014-04
dc.identifier.citation
Ramirez, Juan; Rodriguez, Maria Victoria; Quiroga, Jairo; Abonia, Rodrigo; Sortino, Maximiliano Andrés; et al.; Efficient synthesis under mild reaction conditions of novel 3-aryl-5-(4-chloro-2-morpholinothiazol-5-yl)-4,5-dihydro-1H-pyrazoles and their antifungal activity alone and in combination with commercial antifungal agents.; Wiley VCH Verlag; Archiv Der Pharmazie; 347; 8; 4-2014; 566-575
dc.identifier.issn
0365-6233
dc.identifier.uri
http://hdl.handle.net/11336/29968
dc.description.abstract
The a,b-unsaturated carbonyl compounds 5a–f were prepared by reaction between 2-chloro-4- morpholinothiazol-5-carbaldehyde 3 and substituted acetophenones 4a–f. Treatment of compounds 5a–f with hydrazine hydrate employing mild reaction conditions led to the formation of 4,5-dihydro- 1H-pyrazoles 6a–f. Then the treatment with acetic anhydride or formic acid afforded the expected 4,5- dihydro-1H-pyrazoles 7a–f and 8a–f. The antifungal activity of each series of synthesized compounds was determined against the clinically important fungi Candida albicans and Cryptococcus neoformans. In addition, the most active compounds 7e and 7f were tested in combination with the commercial antifungal agents: fluconazole, itraconazole, and amphotericin B. Compound 7e showed a synergistic effect with fluconazole against C. albicans while 7f showed synergistic activities with all tested antifungal drugs against the same yeast
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antifungal Activity
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2-Chloro-4-Morpholinothiazol-5-Carbaldehyde
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Commercial Antifungal Agents
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4,5- Dihydro-1h-Pyrazoles
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Synergistic Effect
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Efficient synthesis under mild reaction conditions of novel 3-aryl-5-(4-chloro-2-morpholinothiazol-5-yl)-4,5-dihydro-1H-pyrazoles and their antifungal activity alone and in combination with commercial antifungal agents.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-06T17:01:54Z
dc.journal.volume
347
dc.journal.number
8
dc.journal.pagination
566-575
dc.journal.pais
Alemania
dc.journal.ciudad
Weinheim
dc.description.fil
Fil: Ramirez, Juan. Universidad del Valle; Colombia
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Fil: Rodriguez, Maria Victoria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
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Fil: Quiroga, Jairo. Universidad del Valle; Colombia
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Fil: Abonia, Rodrigo. Universidad del Valle; Colombia
dc.description.fil
Fil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Area Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Area Farmacognosia; Argentina
dc.description.fil
Fil: Insuasty, Braulio. Universidad del Valle; Colombia
dc.journal.title
Archiv Der Pharmazie
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ardp.201400084
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ardp.201400084/abstract
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