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dc.contributor.author
Guridi, Jorge
dc.contributor.author
Borgatello, Conrado
dc.contributor.author
Scremin, Oscar Umberto
dc.date.available
2017-12-07T14:16:44Z
dc.date.issued
2014-04
dc.identifier.citation
Guridi, Jorge; Borgatello, Conrado; Scremin, Oscar Umberto; Arginine NO-dependent and NO-independent effects on hemodynamics; Elsevier Science; European Journal of Pharmacology; 729; 4-2014; 138-143
dc.identifier.issn
0014-2999
dc.identifier.uri
http://hdl.handle.net/11336/29905
dc.description.abstract
L-arginine administration decreases mean arterial blood pressure (MABP), presumably by excess nitric oxide (NO) synthesis. However, some reports indicate that D-arginine, not a substrate of NO synthase (NOS), also induces hypotension. To clarify this phenomenon, the hemodynamic effects of L- and D-arginine and their modification by NOS inhibition with L-nitroarginine methyl ester (L-NAME) were assessed. MABP, cardiac output, stroke volume, heart rate and systemic vascular resistance were recorded in Sprague-Dawley rats under urethane or ketamine/diazepam anesthesia, with or without blockade of NO synthesis by L-NAME. Both stereoisomers of arginine induced a dose-related drop in MABP of similar magnitude and time course, but recovery from hypotension was slower in L-arginine than in D-arginine. The hypotension induced by both stereoisomers was due to a decrease in systemic vascular resistance (SVR) with increase in cardiac output (CO) and stroke volume (SV). Administration of L-NAME induced a pronounced increase in MABP and SVR, with decreases in CO and heart rate (HR). Infusion of L-arginine after L-NAME significantly decreased MABP and SVR at the highest dose while D-arginine failed to do so. After L-NAME, MABP was significantly lower under L-arginine than under D-arginine at all doses. These experiments suggest a dual mechanism in the hypotensive effect of L-arginine: a NO independent action on vascular resistance shared with D-arginine, and a NO dependent mechanism that becomes evident in the presence of NOS inhibition with L-NAME. Cardiac effects of NO do not appear to play a role in Larginine hypotension
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
L-Name
dc.subject
Nitric Oxide Synthase
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Arterial Blood Pressure
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Cardiac Output
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Systemic Vascular Resistance
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Arginine NO-dependent and NO-independent effects on hemodynamics
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-06T17:01:52Z
dc.journal.volume
729
dc.journal.pagination
138-143
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Guridi, Jorge. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Borgatello, Conrado. Universidad Nacional de Rosario; Argentina
dc.description.fil
Fil: Scremin, Oscar Umberto. Universidad Nacional de Rosario; Argentina. Greater Los Angeles Healthcare System. Los Angeles; Estados Unidos. David Geffen School of Medicine at UCLA; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
European Journal of Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejphar.2014.01.070
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014299914001162
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