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dc.contributor.author
Rico, Maria Jose
dc.contributor.author
Perroud, Herman Andrés
dc.contributor.author
Mainetti, Leandro Ernesto
dc.contributor.author
Rozados, Viviana Rosa
dc.contributor.author
Scharovsky, Olga Graciela
dc.date.available
2017-12-06T18:22:24Z
dc.date.issued
2014-02
dc.identifier.citation
Rico, Maria Jose; Perroud, Herman Andrés; Mainetti, Leandro Ernesto; Rozados, Viviana Rosa; Scharovsky, Olga Graciela; Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field; Taylor; Cancer Investigation; 32; 3; 2-2014; 92-98
dc.identifier.issn
0735-7907
dc.identifier.uri
http://hdl.handle.net/11336/29853
dc.description.abstract
Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis growth, survival, and toxicity. Metronomic chemotherapy with Cyclophosphamide + Celecoxib (Cy + Cel) showed higher antimetastatic power than Cyclophosphamide + Doxorubicin (Cy + Dox), while being similar in other aspects. That difference, plus the advantage that represents its oral administration, suggests that the Cy + Cel combination is more suitable than Cy + Dox for metronomic chemotherapy of mammary tumors and could be proposed to the translation to the clinic
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Metronomic Chemotherapy
dc.subject
Combined Treatment
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Cyclophosphamide
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Doxorubicin
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Celecoxib
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Mammary Adenocarcinoma
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-06T16:47:31Z
dc.journal.volume
32
dc.journal.number
3
dc.journal.pagination
92-98
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Rico, Maria Jose. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Perroud, Herman Andrés. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Mainetti, Leandro Ernesto. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rozados, Viviana Rosa. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina
dc.description.fil
Fil: Scharovsky, Olga Graciela. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina
dc.journal.title
Cancer Investigation
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/07357907.2013.877480
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/07357907.2013.877480
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