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dc.contributor.author
Barttfeld, Pablo
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Petroni, Agustín
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Báez Buitrago, Sandra Jimena
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Urquina, Hugo
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Sigman, Mariano
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Cetkovich, Marcelo
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Torralva, Teresa
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Torrente, Fernando
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Lischinsky, Alicia
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Castellanos, Xavier
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Manes, Facundo Francisco
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Ibáñez Barassi, Agustín Mariano
dc.date.available
2017-12-04T18:42:06Z
dc.date.issued
2014-02
dc.identifier.citation
Barttfeld, Pablo; Petroni, Agustín; Báez Buitrago, Sandra Jimena; Urquina, Hugo; Sigman, Mariano; et al.; Functional Connectivity and Temporal Variability of Brain Connections in Adults with Attention Deficit/Hyperactivity Disorder and Bipolar Disorder; Karger; Neuropsychobiology; 69; 2; 2-2014; 65-75
dc.identifier.issn
0302-282X
dc.identifier.uri
http://hdl.handle.net/11336/29591
dc.description.abstract
Objectives: To assess brain functional connectivity and variability in adults with attention deficit/hyperactivity disorder (ADHD) or euthymic bipolar disorder (BD) relative to a control (CT) group. Methods: Electroencephalography (EEG) was measured in 35 participants (BD = 11; ADHD = 9; CT = 15) during an eyes-closed 10-min rest period, and connectivity and graph theory metrics were computed. A coefficient of variation (CV) computed also the connectivity’s temporal variability of EEG. Multivariate associations between functional connectivity and clinical and neuropsychological profiles were evaluated. Results: An enhancement of functional connectivity was observed in the ADHD (fronto-occipital connections) and BD (diffuse connections) groups. However, compared with CTs, intrinsic variability (CV) was enhanced in the ADHD group and reduced in the BD group. Graph theory metrics confirmed the existence of several abnormal network features in both affected groups. Significant associations of connectivity with symptoms were also observed. In the ADHD group, temporal variability of functional connections was associated with executive function and memory deficits. Depression, hyperactivity and impulsivity levels in the ADHD group were associated with abnormal intrinsic connectivity. In the BD group, levels of anxiety and depression were related to abnormal frontotemporal connectivity. Conclusions: In the ADHD group, we found that intrinsic variability was associated with deficits in cognitive performance and that connectivity abnormalities were related to ADHD symptomatology. The BD group exhibited less intrinsic variability and more diffuse long-range brain connections, and those abnormalities were related to interindividual differences in depression and anxiety. These preliminary results are relevant for neurocognitive models of abnormal brain connectivity in both disorders.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Intrinsic Variability
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Attention Deficit/Hyperactivity Disorder
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Bipolar Disorder
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Electroencephalography
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Functional Connectivity
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Functional Connectivity and Temporal Variability of Brain Connections in Adults with Attention Deficit/Hyperactivity Disorder and Bipolar Disorder
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-09T14:16:54Z
dc.journal.volume
69
dc.journal.number
2
dc.journal.pagination
65-75
dc.journal.pais
Suiza
dc.description.fil
Fil: Barttfeld, Pablo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Petroni, Agustín. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Báez Buitrago, Sandra Jimena. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Urquina, Hugo. Universidad Favaloro; Argentina
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Fil: Sigman, Mariano. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Cetkovich, Marcelo. Universidad Favaloro; Argentina
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Fil: Torralva, Teresa. Universidad Favaloro; Argentina
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Fil: Torrente, Fernando. Universidad Favaloro; Argentina
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Fil: Lischinsky, Alicia. Universidad Favaloro; Argentina
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Fil: Castellanos, Xavier. New York University. School of Medicine; Estados Unidos
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Fil: Manes, Facundo Francisco. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Ibáñez Barassi, Agustín Mariano. Universidad Favaloro; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Neuropsychobiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000356964
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/356964


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