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Artículo

Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range

Ventura, AlejandraIcon ; Bush, AlanIcon ; Vasen, GustavoIcon ; Goldin, Matías AlejandroIcon ; Burkinshaw, Brianne; Bhattacharjee, Nirveek; Folch, Albert; Brent, Roger; Chernomoretz, ArielIcon ; Colman Lerner, Alejandro ArielIcon
Fecha de publicación: 08/2014
Editorial: National Academy Of Sciences
Revista: Proceedings Of The National Academy Of Sciences Of The United States Of America
ISSN: 0027-8424
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Cell signaling systems sense and respond to ligands that bind cell surface receptors. These systems often respond to changes in the concentration of extracellular ligand more rapidly than the ligand equilibrates with its receptor. We demonstrate, by modeling and experiment, a general “systems level” mechanism cells use to take advantage of the information present in the early signal, before receptor binding reaches a new steady state. This mechanism, preequilibrium sensing and signaling (PRESS), operates in signaling systems in which the kinetics of ligand-receptor binding are slower than the downstream signaling steps, and it typically involves transient activation of a downstream step. In the systems where it operates, PRESS expands and shifts the input dynamic range, allowing cells to make different responses to ligand concentrations so high as to be otherwise indistinguishable. Specifically, we show that PRESS applies to the yeast directional polarization in response to pheromone gradients. Consideration of preexisting kinetic data for ligand-receptor interactions suggests that PRESS operates in many cell signaling systems throughout biology. The same mechanism may also operate at other levels in signaling systems in which a slow activation step couples to a faster downstream step.
Palabras clave: Levaduras , Señalización , Gradiente , Feromona
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/29590
URL: http://www.pnas.org/content/111/37/E3860
DOI: http://dx.doi.org/10.1073/pnas.1322761111
Colecciones
Articulos(IFIBA)
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Ventura, Alejandra; Bush, Alan; Vasen, Gustavo; Goldin, Matías Alejandro; Burkinshaw, Brianne; et al.; Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range; National Academy Of Sciences; Proceedings Of The National Academy Of Sciences Of The United States Of America; 111; 37; 8-2014; 3860-3869
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