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dc.contributor.author
Montaner, Alejandro Daniel
dc.contributor.author
Mongiat, Lucas Alberto
dc.contributor.author
Lux, Victoria Adela R.
dc.contributor.author
Warby, Carol
dc.contributor.author
Chewpoy, Brad
dc.contributor.author
Bianchi, Maria Silvia
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Libertun, Carlos
dc.contributor.author
Rivier, Jean E.
dc.contributor.author
Sherwood, Nancy M.
dc.contributor.author
Somoza, Gustavo Manuel
dc.date.available
2017-12-04T18:40:03Z
dc.date.issued
2002-12
dc.identifier.citation
Montaner, Alejandro Daniel; Mongiat, Lucas Alberto; Lux, Victoria Adela R.; Warby, Carol; Chewpoy, Brad; et al.; Guinea Pig Gonadotropin-Releasing Hormone: Expression Pattern, Characterization and Biological Activity in Rodents; Karger; Neuroendocrinology; 75; 5; 12-2002; 326-338
dc.identifier.issn
0028-3835
dc.identifier.uri
http://hdl.handle.net/11336/29584
dc.description.abstract
Gonadotropin-releasing hormone (GnRH) is a decapeptide widely known for its role in regulating vertebrate reproduction by serving as a signal from the hypothalamus to pituitary gonadotropes. The first form of GnRH to be identified was isolated from mammals (mGnRH) and the same form has been reported for all mammals studied, which includes marsupials and placental mammals. Later, another variant, chicken GnRH-II (cGnRH-II) was shown to be expressed together with mGnRH in the brains of all jawed vertebrates, including mammals such as rats, monkeys and humans. Our objective was to characterize a third form of GnRH that was isolated previously as mRNA from guinea pigs (gpGnRH), but has not been reported for any other mammal to date. Furthermore, the gonadotropic activity of gpGnRH has not been fully characterized. Our results, using chromatographical and immunological methods, show for the first time that gpGnRH is expressed together with mGnRH in some rodents (wild guinea pig and capybara), but not in others (mouse and hamster). Also, the gonadotropic activity of gpGnRH and mGnRH was tested in two different rat cell culture systems. Although there have been reports that the salmon(s) form of GnRH is present in mammals, we did not detect sGnRH in capybara, wild guinea pigs, hamsters, rats or mice. Taken together with previous reports, the present results support the idea that the expression of multiple GnRH variants in a single species is a common pattern in most vertebrate groups
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gonadotropin-Releasing Hormone
dc.subject
Gonadotropin-Releasing Hormone Analogues
dc.subject
Gonadotropins
dc.subject
Reproduction
dc.subject
Comparative Neuroendocrinology
dc.subject
Guinea Pig
dc.title
Guinea Pig Gonadotropin-Releasing Hormone: Expression Pattern, Characterization and Biological Activity in Rodents
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-04T18:00:20Z
dc.journal.volume
75
dc.journal.number
5
dc.journal.pagination
326-338
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Montaner, Alejandro Daniel. Fundación Pablo Cassara; Argentina
dc.description.fil
Fil: Mongiat, Lucas Alberto. Fundación de Instituto de Biología y Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lux, Victoria Adela R.. Fundación de Instituto de Biología y Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Warby, Carol. University Of Victoria; Canadá
dc.description.fil
Fil: Chewpoy, Brad. University Of Victoria; Canadá
dc.description.fil
Fil: Bianchi, Maria Silvia. Fundación de Instituto de Biología y Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Libertun, Carlos. Fundación de Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Rivier, Jean E.. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Sherwood, Nancy M.. University Of Victoria; Canadá
dc.description.fil
Fil: Somoza, Gustavo Manuel. Fundación Pablo Cassara; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
dc.journal.title
Neuroendocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/57342
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000057342


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