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dc.contributor.author
Campbell, Sandra J.
dc.contributor.author
Deacon, Rob M.J.
dc.contributor.author
Jiang, Yanian
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Ferrari, Carina Cintia
dc.contributor.author
Pitossi, Fernando Juan
dc.contributor.author
Anthony, Daniel C.
dc.date.available
2017-12-01T15:07:37Z
dc.date.issued
2007-05
dc.identifier.citation
Campbell, Sandra J.; Deacon, Rob M.J.; Jiang, Yanian; Ferrari, Carina Cintia; Pitossi, Fernando Juan; et al.; Overexpression of IL-1beta by adenoviral-mediated gene transfer in the rat brain causes a prolonged hepatic chemokine response, axonal injury and the suppression of spontaneous behaviour; Academic Press; Neurobiology of Disease; 27; 2; 5-2007; 151-163
dc.identifier.issn
0969-9961
dc.identifier.uri
http://hdl.handle.net/11336/29438
dc.description.abstract
Acute brain injury induces early and transient hepatic expression of chemokines, which amplify the injury response and give rise to movement of leukocytes into the blood and subsequently the brain and liver. Here, we sought to determine whether an ongoing injury stimulus within the brain would continue to drive the hepatic chemokine response and how it impacts on behaviour and CNS integrity. We generated chronic IL-1beta expression in rat brain by adenoviral-mediated gene transfer, which resulted in chronic leukocyte recruitment, axonal injury and prolonged depression of spontaneous behaviour. IL-1beta could not be detected in circulating blood, but a chronic systemic response was established, including extended production of hepatic and circulating chemokines, leukocytosis, liver damage, weight loss, decreased serum albumin and marked liver leukocyte recruitment. Thus, hepatic chemokine synthesis is a feature of active chronic CNS disease and provides an accessible target for the suppression of CNS inflammation
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Adenovirus
dc.subject
Rat
dc.subject
Il-1beta
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Brain
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Overexpression of IL-1beta by adenoviral-mediated gene transfer in the rat brain causes a prolonged hepatic chemokine response, axonal injury and the suppression of spontaneous behaviour
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-11-24T14:39:36Z
dc.identifier.eissn
1095-953X
dc.journal.volume
27
dc.journal.number
2
dc.journal.pagination
151-163
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Diego
dc.description.fil
Fil: Campbell, Sandra J.. University of Oxford; Reino Unido
dc.description.fil
Fil: Deacon, Rob M.J.. University of Oxford; Reino Unido
dc.description.fil
Fil: Jiang, Yanian. University of Oxford; Reino Unido
dc.description.fil
Fil: Ferrari, Carina Cintia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Pitossi, Fernando Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Anthony, Daniel C.. University of Oxford; Reino Unido
dc.journal.title
Neurobiology of Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0969996107000824
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.nbd.2007.04.013
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