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dc.contributor.author
Perez, Federico
dc.contributor.author
Hujer, Andrea M.
dc.contributor.author
Marshall, Steven H.
dc.contributor.author
Ray, Amy, J.
dc.contributor.author
Rather, Philip N.
dc.contributor.author
Suwantaratf, Nuntra
dc.contributor.author
Dumford III, Donald
dc.contributor.author
O'Shea, Patrick
dc.contributor.author
Domitrovic, T. Nicholas J.
dc.contributor.author
Salata, Robert A.
dc.contributor.author
Chavda, Kalyan D.
dc.contributor.author
Chen, Liang
dc.contributor.author
Kreiswirth, Barry N
dc.contributor.author
Vila, Alejandro Jose
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Haussler, Susanne
dc.contributor.author
Jacobs, Michael R.
dc.contributor.author
Bonomo, Robert A.
dc.date.available
2017-12-01T14:13:49Z
dc.date.issued
2014-10
dc.identifier.citation
Perez, Federico; Hujer, Andrea M.; Marshall, Steven H.; Ray, Amy, J.; Rather, Philip N.; et al.; Extensively Drug-Resistant Pseudomonas aeruginosa Isolates Containing blaVIM-2 and Elements of Salmonella Genomic Island 2: a New Genetic Resistance Determinant in Northeast Ohio; American Society For Microbiology; Antimicrobial Agents And Chemotherapy; 58; 10; 10-2014; 5929-5935
dc.identifier.issn
0066-4804
dc.identifier.uri
http://hdl.handle.net/11336/29432
dc.description.abstract
Carbapenems are a mainstay of treatment for infections caused by Pseudomonas aeruginosa. Carbapenem resistance mediated by metallo-β-lactamases (MBLs) remains uncommon in the United States, despite the worldwide emergence of this group of enzymes. Between March 2012 and May 2013, we detected MBL-producing P. aeruginosa in a university-affiliated health care system in northeast Ohio. We examined the clinical characteristics and outcomes of patients, defined the resistance determinants and structure of the genetic element harboring the blaMBL gene through genome sequencing, and typed MBL-producing P. aeruginosa isolates using pulsed-field gel electrophoresis (PFGE), repetitive sequence-based PCR (rep-PCR), and multilocus sequence typing (MLST). Seven patients were affected that were hospitalized at three community hospitals, a long-term-care facility, and a tertiary care center; one of the patients died as a result of infection. Isolates belonged to sequence type 233 (ST233) and were extensively drug resistant (XDR), including resistance to all fluoroquinolones, aminoglycosides, and β-lactams; two isolates were nonsusceptible to colistin. The blaMBL gene was identified as blaVIM-2 contained within a class 1 integron (In559), similar to the cassette array previously detected in isolates from Norway, Russia, Taiwan, and Chicago, IL. Genomic sequencing and assembly revealed that In559 was part of a novel 35-kb region that also included a Tn501-like transposon and Salmonella genomic island 2 (SGI2)-homologous sequences. This analysis of XDR strains producing VIM-2 from northeast Ohio revealed a novel recombination event between Salmonella and P. aeruginosa, heralding a new antibiotic resistance threat in this region's health care system
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society For Microbiology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Carbapenem
dc.subject
Antibiotic Resistance
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Extensively Drug-Resistant Pseudomonas aeruginosa Isolates Containing blaVIM-2 and Elements of Salmonella Genomic Island 2: a New Genetic Resistance Determinant in Northeast Ohio
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-24T19:36:41Z
dc.journal.volume
58
dc.journal.number
10
dc.journal.pagination
5929-5935
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Perez, Federico. Louis Stokes Cleveland Department of Veterans Affairs Medical Center. Cleveland; Estados Unidos. Case Western Reserve University School of Medicine. Cleveland; Estados Unidos
dc.description.fil
Fil: Hujer, Andrea M.. Louis Stokes Cleveland Department of Veterans Affairs Medical Center. Cleveland; Estados Unidos. Case Western Reserve University School of Medicine. Cleveland; Estados Unidos
dc.description.fil
Fil: Marshall, Steven H.. Louis Stokes Cleveland Department of Veterans Affairs Medical Center. Cleveland; Estados Unidos
dc.description.fil
Fil: Ray, Amy, J.. Case Western Reserve University School of Medicine. Cleveland; Estados Unidos. University Hospitals Case Medical Center. Cleveland; Estados Unidos
dc.description.fil
Fil: Rather, Philip N.. Emory University School of Medicine. Atlanta; Estados Unidos. Department of Veterans Affairs Medical Center. Decatur; Estados Unidos
dc.description.fil
Fil: Suwantaratf, Nuntra. University Hospitals Case Medical Center. Cleveland; Estados Unidos
dc.description.fil
Fil: Dumford III, Donald. University Hospitals Case Medical Center. Cleveland; Estados Unidos
dc.description.fil
Fil: O'Shea, Patrick. Louis Stokes Cleveland Department of Veterans Affairs Medical Center. Cleveland; Estados Unidos
dc.description.fil
Fil: Domitrovic, T. Nicholas J.. Louis Stokes Cleveland Department of Veterans Affairs Medical Center. Cleveland; Estados Unidos
dc.description.fil
Fil: Salata, Robert A.. Case Western Reserve University School of Medicine. Cleveland; Estados Unidos. University Hospitals Case Medical Center. Cleveland; Estados Unidos
dc.description.fil
Fil: Chavda, Kalyan D.. Rutgers University; Estados Unidos
dc.description.fil
Fil: Chen, Liang. Rutgers University; Estados Unidos
dc.description.fil
Fil: Kreiswirth, Barry N. Rutgers University; Estados Unidos
dc.description.fil
Fil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Haussler, Susanne. Hannover Medical School and Helmholtz Center for Infection Research; Alemania
dc.description.fil
Fil: Jacobs, Michael R.. Case Western Reserve University School of Medicine. Cleveland; Estados Unidos
dc.description.fil
Fil: Bonomo, Robert A.. Louis Stokes Cleveland Department of Veterans Affairs Medical Center. Cleveland; Estados Unidos. Case Western Reserve University School of Medicine. Cleveland; Estados Unidos
dc.journal.title
Antimicrobial Agents And Chemotherapy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/58/10/5929
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/AAC.02372-14
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