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Artículo

Extensive enriched environments protect old rats from the aging dependent impairment of spatial cognition, synaptic plasticity and nitric oxide production

Lores Arnaiz, SilviaIcon ; Bustamante, J.; Arismendi Angulo, Mardon; Vilas, S.; Paglia, N.; Basso, N.; Capani, FranciscoIcon ; Coirini, HectorIcon ; López, Juan JoséIcon ; Lores Arnaiz, SilviaIcon
Fecha de publicación: 02/2006
Editorial: Elsevier Science
Revista: Behavioural Brain Research
ISSN: 0166-4328
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Químicas

Resumen

In aged rodents, neuronal plasticity decreases while spatial learning and working memory (WM) deficits increase. As it is well known, rats reared in enriched environments (EE) show better cognitive performances and an increased neuronal plasticity than rats reared in standard environments (SE). We hypothesized that EE could preserve the aged animals from cognitive impairment through NO dependent mechanisms of neuronal plasticity. WM performance and plasticity were measured in 27-month-old rats from EE and SE. EE animals showed a better spatial WM performance (66% increase) than SE ones. Cytosolic NOS activity was 128 and 155% higher in EE male and female rats, respectively. Mitochondrial NOS activity and expression were also significantly higher in EE male and female rats. Mitochondrial NOS protein expression was higher in brain submitochondrial membranes from EE reared rats. Complex I activity was 70–80% increased in EE as compared to SE rats. A significant increase in the area of NADPH-d reactive neurons was observed in the parietotemporal cortex and CA1 hippocampal region of EE animals.
Palabras clave: Aging , Nadph Diaphorase , Cognition , Enriched Environment , Working Memory , Brain Plasticity , Nitric Oxide Synthase , Mitochondrial Respiratory Complexes , Aged Rats
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/29221
URL: http://www.sciencedirect.com/science/article/pii/S0166432806000672
DOI: http://dx.doi.org/10.1016/j.bbr.2006.01.016
Colecciones
Articulos(IBCN)
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Articulos(IBIMOL)
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Lores Arnaiz, Silvia; Bustamante, J.; Arismendi Angulo, Mardon; Vilas, S.; Paglia, N.; et al.; Extensive enriched environments protect old rats from the aging dependent impairment of spatial cognition, synaptic plasticity and nitric oxide production; Elsevier Science; Behavioural Brain Research; 169; 2; 2-2006; 294-302
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