Mostrar el registro sencillo del ítem

dc.contributor.author
Simian, Marina
dc.contributor.author
Molinolo, Alfredo
dc.contributor.author
Lanari, Claudia Lee Malvina
dc.date.available
2017-11-23T12:47:45Z
dc.date.issued
2006-12
dc.identifier.citation
Simian, Marina; Molinolo, Alfredo; Lanari, Claudia Lee Malvina; Involvement of matrix metalloproteinase activity in hormone-induced mammary tumor regression; Amer Soc Investigative Pathology, Inc; American Journal Of Pathology; 168; 1; 12-2006; 270-279
dc.identifier.issn
0002-9440
dc.identifier.uri
http://hdl.handle.net/11336/28811
dc.description.abstract
Proteolytic activity and remodeling of the extracellular matrix are important players in tumor progression. However, to date the role of the extracellular matrix in tumor regression remains unresolved. To address this, we used a progesterone-dependent in vivo mouse mammary tumor line, C4-HD, which regresses in response to hormone therapy. Within the first 72 hours of treatment, massive apoptosis was accompanied by changes in the staining patterns of laminin and collagens I, III, and IV. We thus hypothesized that an increase in matrix metalloproteinase (MMP) activity could be involved in this process. This indeed was the case as the activities of MMP-2, -9, and -3 increased in regressing tumors, coinciding with the peak of apoptosis. Moreover, cell-cell interactions were disrupted during early hours of regression with E-cadherin levels reduced and fragmentation products detected during regression. Analysis of β-catenin revealed that although total levels within the tissue did not change, this molecule switched from being involved in cell-cell adhesion in the growing tumor to being expressed in the reactive stroma during regression. Our data provide a novel role for proteolytic activity in tumor regression and question the underlying principle for using MMP inhibitors in cancer treatment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Amer Soc Investigative Pathology, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mammary Carcinomas
dc.subject
Stroma
dc.subject
Tumor Regression
dc.subject
Antiprogestins
dc.subject
Cancer
dc.subject.classification
Patología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Involvement of matrix metalloproteinase activity in hormone-induced mammary tumor regression
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-26T14:50:16Z
dc.identifier.eissn
1525-2191
dc.journal.volume
168
dc.journal.number
1
dc.journal.pagination
270-279
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Simian, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Molinolo, Alfredo. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title
American Journal Of Pathology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0002944010620895
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2353/ajpath.2006.050012
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592671/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/16400029


Archivos asociados

Documento no disponible

Comunidades y colecciones

Mostrar el registro sencillo del ítem