Artículo
Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation
Fecha de publicación:
05/2006
Editorial:
Elsevier Science
Revista:
Autoimmunity Reviews
ISSN:
1568-9972
e-ISSN:
1873-0183
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Protein-glycan interactions control essential immunological processes, including T-cell activation, differentiation and survival. Galectins, carbohydrate-binding proteins, defined by shared consensus amino acid sequences and affinity for beta-galactose-containing oligosaccharides, participate in a wide spectrum of immunological processes. These carbohydrate-binding proteins regulate the development of pathogenic T-cell responses by influencing T-cell survival, activation and cytokine secretion. Administration of recombinant galectins or their genetic delivery modulate the development and severity of chronic inflammatory responses in experimental models of autoimmunity by triggering different and potentially overlapping immunoregulatory mechanisms. Given the potential use of galectins as novel anti-inflammatory agents or targets for immunosuppressive drugs, we will summarize here recent findings on the influence of these carbohydrate-binding proteins in autoimmune and chronic inflammatory disorders.
Palabras clave:
Apoptosis
,
Autoimmunity
,
Galectins
,
Glycosylation
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Bianco, German Ariel; Toscano, Marta Alicia; Ilarregui, Juan Martin; Rabinovich, Gabriel Adrián; Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation; Elsevier Science; Autoimmunity Reviews; 5; 5; 5-2006; 349-356
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