Mostrar el registro sencillo del ítem
dc.contributor.author
Rabinovich, Gabriel Adrián
dc.contributor.author
Cumashi, Albana
dc.contributor.author
Bianco, German Ariel
dc.contributor.author
Ciavardelli, Domenico
dc.contributor.author
Iurisci, Ida
dc.contributor.author
D’Egidio, Maurizia
dc.contributor.author
Piccolo, Enza
dc.contributor.author
Tinari, Nicola
dc.contributor.author
Nifantiev, Nikolay
dc.contributor.author
Iacobelli, Stefano
dc.date.available
2017-11-18T10:38:43Z
dc.date.issued
2006-03
dc.identifier.citation
Rabinovich, Gabriel Adrián; Cumashi, Albana; Bianco, German Ariel; Ciavardelli, Domenico; Iurisci, Ida; et al.; Synthetic lactulose amines: novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial cell morphogenesis; Oxford Univ Press Inc; Glycobiology; 16; 3; 3-2006; 210-220
dc.identifier.issn
0959-6658
dc.identifier.uri
http://hdl.handle.net/11336/28531
dc.description.abstract
Galectins, a family of structurally related carbohydrate-binding proteins, contribute to different events associated with cancer biology, including apoptosis, homotypic cell aggregation, angiogenesis and tumor-immune escape. To interfere with galectin-carbohydrate interactions during tumor progression, a current challenge is the design of specific galectin inhibitors for therapeutic purposes. Here, we report the synthesis of three novel low molecular weight synthetic lactulose amines (SLA): (1) N-lactulose-octamethylenediamine (LDO), (2) N,N´-dilactulose-octamethylenediamine (D-LDO), and (3) N,N´-dilactulose-dodecamethylenediamine (D-LDD). These compounds showed a differential ability to inhibit binding of galectin-1 and/or galectin-3 to the highly glycosylated protein 90K in solid-phase assays. In addition, each compound demonstrated selective regulatory effects in different events linked to tumor progression including tumor-cell apoptosis, homotypic cell aggregation, and endothelial cell morphogenesis. Our results suggest that galectin inhibitors with subtle differences in their carbohydrate structures may be potentially used to specifically block different steps of tumor growth and metastasis
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford Univ Press Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antineoplastic Agents
dc.subject
Apoptosis
dc.subject
Endothelial Cells
dc.subject
Galectin
dc.subject
Glycosylation
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Synthetic lactulose amines: novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial cell morphogenesis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-26T14:40:09Z
dc.identifier.eissn
1460-2423
dc.journal.volume
16
dc.journal.number
3
dc.journal.pagination
210-220
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Cumashi, Albana. Università degli Studi G. D´Annunzio; Italia
dc.description.fil
Fil: Bianco, German Ariel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Ciavardelli, Domenico. Università degli Studi G. D´Annunzio; Italia
dc.description.fil
Fil: Iurisci, Ida. Università degli Studi G. D´Annunzio; Italia
dc.description.fil
Fil: D’Egidio, Maurizia. Università degli Studi G. D´Annunzio; Italia
dc.description.fil
Fil: Piccolo, Enza. Università degli Studi G. D´Annunzio; Italia
dc.description.fil
Fil: Tinari, Nicola. Università degli Studi G. D´Annunzio; Italia
dc.description.fil
Fil: Nifantiev, Nikolay. Academia de Ciencias Rusa; Rusia
dc.description.fil
Fil: Iacobelli, Stefano. Università degli Studi G. D´Annunzio; Italia
dc.journal.title
Glycobiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/glycob/article/16/3/210/716073
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/glycob/cwj056
Archivos asociados