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dc.contributor.author
Mancini, Jorge Eduardo
dc.contributor.author
Croxatto, Juan Oscar
dc.contributor.author
Gallo, Juan Eduardo Maria
dc.date.available
2017-11-17T14:41:02Z
dc.date.issued
2013-11
dc.identifier.citation
Mancini, Jorge Eduardo; Croxatto, Juan Oscar; Gallo, Juan Eduardo Maria; Proliferative retinopathy and neovascularization of the anterior segment in female type 2 diabetic rats; BioMed Central; Diabetology & metabolic syndrome; 5; 1; 11-2013; 68-76
dc.identifier.issn
1758-5996
dc.identifier.uri
http://hdl.handle.net/11336/28422
dc.description.abstract
Background: To examine the presence of diabetic retinopathy in a female rat model of type 2 diabetes fed on a high-fat diet (HFD). Methods: Wistar rats were injected with streptozotocin (STZ) at the age of two days and fed on an HFD from eight weeks onwards. Five diabetic animals were euthanized at 110 weeks of disease, together with a control group of age-matched, non-diabetic animals. A group of diabetic animals at 57 weeks of disease was included for comparison. Cross sections of the rats’ corneas, iris and retinas were histologically examined and analysed by immunohistochemistry and immunofluorescence, using glial-fibrillary-acidic-protein (GFAP), the vascular endothelial growth factor (VEGF) and the Von Willebrand factor (vWF). The trypsine digestive technique was used for the pericytes count. Results: Neovascularization was only found in the retinas, irises and corneas of the diabetic animals of 110 weeks of disease. There was also a significantly lower number of pericytes in these animals than in the controls. Conclusion: The female rat model of type 2 diabetes fed on an HFD may prove useful in evaluating the mechanisms involved in diabetic retinopathy, together with strategies to reduce its severity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Type 2 Diabetes
dc.subject
Diabetic Retinopathy
dc.subject
Diet
dc.subject
Neovascularization
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Animal Model
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Proliferative retinopathy and neovascularization of the anterior segment in female type 2 diabetic rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-11-17T13:45:47Z
dc.journal.volume
5
dc.journal.number
1
dc.journal.pagination
68-76
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Mancini, Jorge Eduardo. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Croxatto, Juan Oscar. Fundación Oftalmología Argentina "J. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gallo, Juan Eduardo Maria. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Diabetology & metabolic syndrome
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://dmsjournal.biomedcentral.com/articles/10.1186/1758-5996-5-68
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/1758-5996-5-68


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