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dc.contributor.author Cárdenas, Nivia
dc.contributor.author Laiño, Jonathan Emiliano
dc.contributor.author Delgado, Susana
dc.contributor.author Jiménez, Esther
dc.contributor.author Juarez del Valle, Marianela
dc.contributor.author Savoy, Graciela
dc.contributor.author Sesma, Fernando Juan Manuel
dc.contributor.author Mayo, Baltasar
dc.contributor.author Fernández, Leónides
dc.contributor.author Leblanc, Jean Guy Joseph
dc.contributor.author Rodríguez, Juan M.
dc.date.available 2017-11-16T20:31:23Z
dc.date.issued 2015-05-10
dc.identifier.citation Cárdenas, Nivia; Laiño, Jonathan Emiliano; Delgado, Susana; Jiménez, Esther; Juarez del Valle, Marianela; et al.; Relationships between the genome and some phenotypical properties of Lactobacillus fermentum CECT 5716, a probiotic strain isolated from human milk; Springer; Applied Microbiology and Biotechnology; 99; 10; 10-5-2015; 4343-4353
dc.identifier.issn 0175-7598
dc.identifier.uri http://hdl.handle.net/11336/28385
dc.description.abstract Lactobacillus fermentum CECT 5716, isolated from human milk, has immunomodulatory, anti-inflammatory and antiinfectious properties, as revealed by several in vitro and in vivo assays, which suggests a strong potential as a probiotic strain. In this work, some phenotypic properties of L. fermentum CECT 5716 were evaluated and the genetic basis for the obtained results was searched for in the strain genome. L. fermentum CECT 5716 does not contain plasmids and showed neither bacteriocin nor biogenic amines biosynthesis ability but was able to produce organic acids, glutathione, riboflavin, and folates, and to moderately stimulate the maturation of mouse dendritic cells. No prophages could be induced and the strain was sensitive to all antibiotics proposed by EFSA standards while no transmissible genes potentially involved in antibiotic resistance were detected in its genome. Comparison with the genome of L. fermentum IFO3956 revealed the presence of 15 protein-encoding genes that were only found in that of L. fermentum CECT 5716. Globally, there was an agreement between the phenotype properties of L. fermentum CECT 5716 and the genetic information contained in its genome.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject LACTOBACILLUS FERMENTUM
dc.subject GENOME
dc.subject GLUTATHIONE
dc.subject RIBOFLAVINE
dc.subject FOLATE
dc.subject ANTIBIOTIC RESISTANCE
dc.subject DENDRITIC CELLS
dc.subject HUMAN MILK
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.subject.classification Alimentos y Bebidas
dc.subject.classification Otras Ingenierías y Tecnologías
dc.subject.classification INGENIERÍAS Y TECNOLOGÍAS
dc.title Relationships between the genome and some phenotypical properties of Lactobacillus fermentum CECT 5716, a probiotic strain isolated from human milk
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-07-04T14:09:30Z
dc.identifier.eissn 1432-0614
dc.journal.volume 99
dc.journal.number 10
dc.journal.pagination 4343-4353
dc.journal.pais Alemania
dc.journal.ciudad Berlin
dc.description.fil Fil: Cárdenas, Nivia. Universidad Complutense de Madrid; España
dc.description.fil Fil: Laiño, Jonathan Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil Fil: Delgado, Susana. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
dc.description.fil Fil: Jiménez, Esther. Universidad Complutense de Madrid; España
dc.description.fil Fil: Juarez del Valle, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil Fil: Savoy, Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil Fil: Sesma, Fernando Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil Fil: Mayo, Baltasar. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
dc.description.fil Fil: Fernández, Leónides. Universidad Complutense de Madrid; España
dc.description.fil Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil Fil: Rodríguez, Juan M.. Universidad Complutense de Madrid; España
dc.journal.title Applied Microbiology and Biotechnology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00253-015-6429-0
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00253-015-6429-0


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)