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dc.contributor.author
Cárdenas, Nivia
dc.contributor.author
Laiño, Jonathan Emiliano
dc.contributor.author
Delgado, Susana
dc.contributor.author
Jiménez, Esther
dc.contributor.author
Juarez del Valle, Marianela
dc.contributor.author
Savoy, Graciela
dc.contributor.author
Sesma, Fernando Juan Manuel
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Mayo, Baltasar
dc.contributor.author
Fernández, Leónides
dc.contributor.author
Leblanc, Jean Guy Joseph
dc.contributor.author
Rodríguez, Juan M.
dc.date.available
2017-11-16T20:31:23Z
dc.date.issued
2015-05-10
dc.identifier.citation
Cárdenas, Nivia; Laiño, Jonathan Emiliano; Delgado, Susana; Jiménez, Esther; Juarez del Valle, Marianela; et al.; Relationships between the genome and some phenotypical properties of Lactobacillus fermentum CECT 5716, a probiotic strain isolated from human milk; Springer; Applied Microbiology and Biotechnology; 99; 10; 10-5-2015; 4343-4353
dc.identifier.issn
0175-7598
dc.identifier.uri
http://hdl.handle.net/11336/28385
dc.description.abstract
Lactobacillus fermentum CECT 5716, isolated from human milk, has immunomodulatory, anti-inflammatory and antiinfectious properties, as revealed by several in vitro and in vivo assays, which suggests a strong potential as a probiotic strain. In this work, some phenotypic properties of L. fermentum CECT 5716 were evaluated and the genetic basis for the obtained results was searched for in the strain genome. L. fermentum CECT 5716 does not contain plasmids and showed neither bacteriocin nor biogenic amines biosynthesis ability but was able to produce organic acids, glutathione, riboflavin, and folates, and to moderately stimulate the maturation of mouse dendritic cells. No prophages could be induced and the strain was sensitive to all antibiotics proposed by EFSA standards while no transmissible genes potentially involved in antibiotic resistance were detected in its genome. Comparison with the genome of L. fermentum IFO3956 revealed the presence of 15 protein-encoding genes that were only found in that of L. fermentum CECT 5716. Globally, there was an agreement between the phenotype properties of L. fermentum CECT 5716 and the genetic information contained in its genome.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lactobacillus Fermentum
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Genome
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Glutathione
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Riboflavine
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Folate
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Antibiotic Resistance
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Dendritic Cells
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Human Milk
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Alimentos y Bebidas
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Otras Ingenierías y Tecnologías
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Relationships between the genome and some phenotypical properties of Lactobacillus fermentum CECT 5716, a probiotic strain isolated from human milk
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-04T14:09:30Z
dc.identifier.eissn
1432-0614
dc.journal.volume
99
dc.journal.number
10
dc.journal.pagination
4343-4353
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Cárdenas, Nivia. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Laiño, Jonathan Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Delgado, Susana. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
dc.description.fil
Fil: Jiménez, Esther. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Juarez del Valle, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Savoy, Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Sesma, Fernando Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Mayo, Baltasar. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
dc.description.fil
Fil: Fernández, Leónides. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Rodríguez, Juan M.. Universidad Complutense de Madrid; España
dc.journal.title
Applied Microbiology and Biotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00253-015-6429-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00253-015-6429-0


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