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dc.contributor.author
Antonini, Angelo
dc.contributor.author
Calandrella, Daniela
dc.contributor.author
Merello, Marcelo Jorge
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Konstantinos, Koutsikos
dc.contributor.author
Pilleri, Manuela
dc.date.available
2017-11-15T18:10:00Z
dc.date.issued
2013-12
dc.identifier.citation
Antonini, Angelo; Calandrella, Daniela; Merello, Marcelo Jorge; Konstantinos, Koutsikos; Pilleri, Manuela; Effects of rotigotine on Parkinson´s disease-related sleep disturbances; Taylor & Francis; Expert Opinion On Therapeutic Targets; 14; 18; 12-2013; 2571-2580
dc.identifier.issn
1472-8222
dc.identifier.uri
http://hdl.handle.net/11336/28254
dc.description.abstract
INTRODUCTION: Sleep abnormalities are a frequent non-motor symptom and a prominent cause of disability in patients with Parkinson's disease (PD).
AREAS COVERED: This review discusses what is currently known about the characteristics of sleep disturbances in PD patients and attempts to clarify the role of dopaminergic pathways in their pathogenesis as well as the beneficial effect of dopaminergic agents in their treatment. In particular, this review will focus on the effects of transdermal rotigotine on improving PD-related sleep disorders.
EXPERT OPINION: Sleep disturbances are common in PD, and these disturbances can be reduced or resolved, in large part, by preventing or attenuating nocturnal and early morning motor and non-motor symptoms of PD. The studies discussed within this review suggest that sleep disorders are not just a consequence of motor impairment and dopaminergic therapy but are an integral part of the neurodegenerative process of PD. This is supported by the appearance of specific sleep disturbances, which are related to degeneration of the brainstem areas involved in the regulation of sleep/wake states in advance of typical PD symptoms. Development of more detailed diagnostic tools aimed at detecting sleep disturbances and at defining the main causative factors of sleep disturbances in PD will lead to improved treatment of these disturbances.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dopamine
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Rotigotine
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Parkinson´S Disease
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Sleep Disturbance
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Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effects of rotigotine on Parkinson´s disease-related sleep disturbances
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-11-15T13:49:44Z
dc.journal.volume
14
dc.journal.number
18
dc.journal.pagination
2571-2580
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Antonini, Angelo. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorders; Italia
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Fil: Calandrella, Daniela. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorders; Italia
dc.description.fil
Fil: Merello, Marcelo Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Konstantinos, Koutsikos. Università di Padova; Italia
dc.description.fil
Fil: Pilleri, Manuela. IRCCS San Camilo. Department for Parkinson's Disease and Movement Disorder; Italia
dc.journal.title
Expert Opinion On Therapeutic Targets
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1517/14656566.2013.849692
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1517/14656566.2013.849692
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