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Artículo

Antifungal susceptibility of malassezia furfur, malassezia sympodialis and malassezia globosa to azole drugs and amphotericin B evaluated using a broth microdilution method

Rojas, Florencia DinorahIcon ; Sosa, Maria de Los Angeles; Fernández, Mariana SoledadIcon ; Cattana, Maria EmiliaIcon ; Córdoba, Susana Beatríz; Giusiano, Gustavo EmilioIcon
Fecha de publicación: 08/2014
Editorial: Taylor & Francis Ltd
Revista: Medical Mycology
ISSN: 1369-3786
e-ISSN: 1460-2709
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias de la Salud

Resumen

We studied the in vitro activity of fluconazole (FCZ), ketoconazole (KTZ), miconazole (MCZ), voriconazole (VCZ), itraconazole (ITZ) and amphotericin B (AMB) against the three major pathogenic Malassezia species, M. globosa, M. sympodialis, andM. furfur. Antifungal susceptibilities were determined using the broth microdilution method in accordance with Clinical and Laboratory Standards Institute reference document M27-A3. To support lipid-dependent yeast development, glucose, peptone, ox bile,malt extract, glycerol, and Tween supplements were added to Roswell Park Memorial Institute RPMI 1640 medium. The supplemented medium allowed good growth of all three species studied. The minimal inhibitory concentrations (MICs) were recorded after 72 h of incubation at 32oC. The three species showed different susceptibility profiles for the drugs tested. Malassezia sympodialis was the most susceptible and M. furfur the least susceptible species. KTZ, ITZ, and VCZ were the most active drugs, showing low variability among isolates of the same species. FCZ, MCZ, and AMB showed high MICs and wide MIC ranges. Differences observed emphasize the need to accurately identify and evaluate antifungal susceptibility of Malassezia species. Further investigations and collaborative studies are essential for correlating in vitro results with clinical outcomes since the existing limited data do not allow definitive conclusions.
Palabras clave: Malassezia , Susceptibility , Broth Microdilution , Azole Drug , Amphotericin B.
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/28148
DOI: http://dx.doi.org/10.1093/mmy/myu010
URL: https://academic.oup.com/mmy/article/52/6/641/2802489
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Articulos(CCT - NORDESTE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NORDESTE
Citación
Rojas, Florencia Dinorah; Sosa, Maria de Los Angeles; Fernández, Mariana Soledad; Cattana, Maria Emilia; Córdoba, Susana Beatríz; et al.; Antifungal susceptibility of malassezia furfur, malassezia sympodialis and malassezia globosa to azole drugs and amphotericin B evaluated using a broth microdilution method; Taylor & Francis Ltd; Medical Mycology; 52; 6; 8-2014; 641-646
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