Artículo

Copper(II) complexes of methimazole, an anti Grave’s disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor

Urquiza, Nora María; Manca, Silvia Graciela; Moyano, María A.; Dellmans, Raquel Arrieta; Lezama, Luis; Rojo, Teófilo; Naso, Luciana GissellaIcon ; Williams, Patricia Ana María; Ferrer, Evelina GloriaIcon
Fecha de publicación: 04/2010
Editorial: Springer
Revista: Biometals
ISSN: 0966-0844
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Methimazole (MeimzH) is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)2(NO3)2].0.5H2O and [Cu(MeimzH)2 (H2O)2](NO3)2 H2O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated.
Palabras clave: METHIMAZOLE , COOPER , GRAVE´S DISEASE , EPR
 
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/279174
URL: https://link.springer.com/article/10.1007/s10534-009-9283-7
DOI: http://dx.doi.org/10.1007/s10534-009-9283-7
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Articulos(CEQUINOR)
Articulos de CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Citación
Urquiza, Nora María; Manca, Silvia Graciela; Moyano, María A.; Dellmans, Raquel Arrieta; Lezama, Luis; et al.; Copper(II) complexes of methimazole, an anti Grave’s disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor; Springer; Biometals; 23; 2; 4-2010; 255-264
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