Shiga toxin-producing Escherichia coli , food contamination, and bacteriophages as a control strategy

Abstract

Shiga toxin-producing Escherichia coli (STEC) strains cause diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS) in humans. HUS is a severe systemic illness that can affect individuals of all ages, especially children. There is no specific treatment for HUS and interventions consist of supportive therapy. STEC infections occur worldwide and severe illness may occur in sporadic cases or outbreaks. In 2023, STEC was the third most frequently reported zoonotic agent detected in foodborne outbreaks in the EU. In this manuscript, we have focused on STEC reservoirs, STEC contamination of foods, source attribution of STEC infections, and current discussions about the pathogenic potential of STEC strains present in foods. Considering that food contamination with STEC represents a serious threat to public health, that preventive strategies for STEC infection are critical, and natural antimicrobials have gained an increasing interest, we also present thoroughly revised information about bacteriophages as a strategy for STEC control. We also discussed the main aspects of the performance of commercial and non-commercial bacteriophages on foods artificially contaminated with STEC.