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dc.contributor.author
Kumagae, Naosuke
dc.contributor.author
Villena, Julio Cesar
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dc.contributor.author
Tomosada, Yohsuke
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Kobayashi, Hisakazu
dc.contributor.author
Kanmani, Paulraj
dc.contributor.author
Aso, Hisashi
dc.contributor.author
Sasaki, Takashi
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Yoshida, Motohiko
dc.contributor.author
Tanabe, Hiroshi
dc.contributor.author
Shibata, Isao
dc.contributor.author
Saito, Tadao
dc.contributor.author
Kitazawa, Haruki
dc.date.available
2015-11-13T14:38:21Z
dc.date.issued
2014-03
dc.identifier.citation
Kumagae, Naosuke; Villena, Julio Cesar; Tomosada, Yohsuke; Kobayashi, Hisakazu ; Kanmani, Paulraj; et al.; Evaluation of the immunoregulatory capacities of feed microbial materials in porcine intestinal immune and epithelial cells.; Scientific Research; Open Journal of Veterinary Medicine; 4; 3; 3-2014; 15-28
dc.identifier.issn
2165-3356
dc.identifier.uri
http://hdl.handle.net/11336/2777
dc.description.abstract
The establishment of drug-free feeding systems has been required for secure and healthy lives- tock production. Although functional feed materials containing microorganisms as alternatives to enhance intestinal immunity are expected to be beneficial for reducing diarrhoea caused by pathogens in weaned piglets, the effects of such materials on porcine intestinal cells have not been investigated in detail. Therefore, this work evaluated the immunoregulatory functions of microbial feed materials in porcine intestinal immune and epithelial cells. Porcine immune cells isolated from Peyer?s patches and mesenteric lymph nodes were stimulated with six different feed materials containing microorganisms, and evaluated for lymphocyte mitogenicity and cytokine inductions. In addition, porcine intestinal epithelial cells were stimulated with the materials before treatment with heat-killed enterotoxigenic Escherichia coli (ETEC), and analyzed for the proinflammatory cytokine expressions. The material containing Bifidobacterium thermophilum significantly augmented lymphocytes? mitogenicity and also induced a high expression of IL-2, IL-6 and IFN-γ in immune cells, and inhibited ETEC-induced overexpression of IL-6 and IL-8 via regulation of Toll-like receptor signaling. These results suggest that this feed material stimulates intestinal epithelial and immune cells to exert immunoregulation, suggesting that this feed is expected to contribute to promoting the health of piglets without using antimicrobial feed materials.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Scientific Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Feed Microbial Material
dc.subject
Immunoregulatory Effect
dc.subject
Porcine Intestinal Epitheliocytes
dc.subject
Porcine Immune Cells
dc.subject.classification
Biotecnología relacionada con la Salud
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dc.subject.classification
Biotecnología de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Evaluation of the immunoregulatory capacities of feed microbial materials in porcine intestinal immune and epithelial cells.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
2165-3364
dc.journal.volume
4
dc.journal.number
3
dc.journal.pagination
15-28
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Irvine, CA
dc.conicet.avisoEditorial
Copyright © 2014 by authors and Scientific Research Publishing Inc.
This work is licensed under the Creative Commons Attribution International License (CC BY).
http://creativecommons.org/licenses/by/4.0/
dc.description.fil
Fil: Kumagae, Naosuke. Tohoku University. Graduate School of Agricultural Science. Laboratory of Animal Products Chemistry. Food and Feed Immunology Group; Japón. Scientific Feed Laboratory Co. Ltd.; Japón
dc.description.fil
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina. Tohoku University. Graduate School of Agricultural Science. Laboratory of Animal Products Chemistry. Food and Feed Immunology Group; Japón
dc.description.fil
Fil: Tomosada, Yohsuke. Tohoku University. Graduate School of Agricultural Science. Laboratory of Animal Products Chemistry. Food and Feed Immunology Group; Japón
dc.description.fil
Fil: Kobayashi, Hisakazu . Tohoku University. Graduate School of Agricultural Science. Laboratory of Animal Products Chemistry. Food and Feed Immunology Group; Japón
dc.description.fil
Fil: Kanmani, Paulraj. Tohoku University. Graduate School of Agricultural Science. Laboratory of Animal Products Chemistry. Food and Feed Immunology Group; Japón. Japan Society for the Promotion of Science; Japón
dc.description.fil
Fil: Aso, Hisashi . Tohoku University. Graduate School of Agricultural Science. Cell Biology Laboratory; Japón
dc.description.fil
Fil: Sasaki, Takashi . Scientific Feed Laboratory Co. Ltd.; Japón
dc.description.fil
Fil: Yoshida, Motohiko . Scientific Feed Laboratory Co. Ltd.; Japón
dc.description.fil
Fil: Tanabe, Hiroshi. Scientific Feed Laboratory Co. Ltd.; Japón
dc.description.fil
Fil: Shibata, Isao. Scientific Feed Laboratory Co. Ltd.; Japón
dc.description.fil
Fil: Saito, Tadao . Tohoku University. Graduate School of Agricultural Science. Laboratory of Animal Products Chemistry. Food and Feed Immunology Group; Japón
dc.description.fil
Fil: Kitazawa, Haruki. Tohoku University. Graduate School of Agricultural Science. Laboratory of Animal Products Chemistry. Food and Feed Immunology Group; Japón
dc.journal.title
Open Journal of Veterinary Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4236/ojvm.2014.43003
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.scirp.org/Journal/Home.aspx?IssueID=4563#.VkTqc9IrJkg
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.scirp.org/journal/ojvm
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