Mostrar el registro sencillo del ítem

dc.contributor.author
LLavero, Francisco  
dc.contributor.author
Artaso, Alain  
dc.contributor.author
Lacerda, Hadriano M.  
dc.contributor.author
Parada, Luis Antonio  
dc.contributor.author
Zugaza, José L.  
dc.date.available
2017-11-07T13:30:32Z  
dc.date.issued
2016-08  
dc.identifier.citation
LLavero, Francisco; Artaso, Alain; Lacerda, Hadriano M.; Parada, Luis Antonio; Zugaza, José L.; Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway; Elsevier Science Inc; Cellular Signalling; 28; 11; 8-2016; 1713-1724  
dc.identifier.issn
0898-6568  
dc.identifier.uri
http://hdl.handle.net/11336/27716  
dc.description.abstract
Recently, we have reported that the IL-2-stimulated T cells activate PKCθ in order to phosphorylate the serine residues of αPIX-RhoGEF, and to switch on the Rac1/PYGM pathway resulting in T cell migration and proliferation. However, the molecular mechanism connecting the activated IL-2-R with the PKCθ/αPIX/Rac1/PYGM pathway is still unknown. In this study, the use of a combined pharmacological and genetic approach identified Lck, a Src family member, as the tyrosine kinase phosphorylating PLCγ leading to Rac1 and PYGM activation in the IL-2-stimulated Kit 225 T cells via the PKCθ/αPIX pathway. The PLCγ tyrosine phosphorylation was required to activate first PKCθ, and then αPIX and Rac1/PYGM. The results presented here delineate a novel signalling pathway ranking equally in importance to the three major pathways controlled by the IL-2-R, i.e. PI3K, Ras/MAPK and JAK/STAT pathways. The overall evidence strongly indicates that the central biological role of the novel IL-2-R/Lck/PLCγ/PKCθ/αPIX/Rac1/PYGM signalling pathway is directly related to the control of fundamental cellular processes such as T cell migration and proliferation.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Cell Migration And Proliferation  
dc.subject
Glycogen Phosphorylase  
dc.subject
Phosphoserine  
dc.subject
Rac1  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-09-01T18:06:45Z  
dc.journal.volume
28  
dc.journal.number
11  
dc.journal.pagination
1713-1724  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: LLavero, Francisco. Universidad del País Vasco; España. Achucarro Basque Center for Neuroscience; España  
dc.description.fil
Fil: Artaso, Alain. Universidad del País Vasco; España  
dc.description.fil
Fil: Lacerda, Hadriano M.. Universidad del País Vasco; España  
dc.description.fil
Fil: Parada, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina  
dc.description.fil
Fil: Zugaza, José L.. Achucarro Basque Center for Neuroscience; España. Universidad del País Vasco; España  
dc.journal.title
Cellular Signalling  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0898656816301930?via%3Dihub  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cellsig.2016.07.014