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dc.contributor.author
Musolino, Patricia Leonor
dc.contributor.author
Coronel, Maria Florencia
dc.contributor.author
Hökfelt, Tomas
dc.contributor.author
Villar, Marcelo José
dc.date.available
2017-11-03T01:09:21Z
dc.date.issued
2007-05-11
dc.identifier.citation
Musolino, Patricia Leonor; Coronel, Maria Florencia; Hökfelt, Tomas; Villar, Marcelo José; Bone marrow stromal cells induce changes in pain behavior after sciatic nerve constriction; Elsevier Ireland; Neuroscience Letters; 418; 1; 11-5-2007; 97-101
dc.identifier.issn
0304-3940
dc.identifier.uri
http://hdl.handle.net/11336/27524
dc.description.abstract
Peripheral nerve injury, i.e. a single ligature nerve constriction (SLNC), triggers neuropathic pain. Bone marrow stromal cells (MSCs) have been observed to migrate to the injured tissues and mediate functional recovery following brain, spinal cord and peripheral nerve lesions. We have recently shown MSC selective migration to the ipsilateral lumbar (L3-6) dorsal root ganglia (DRGs) after a sciatic nerve SLNC. In this study, we have analyzed the thermal and mechanical sensitivities of animals subjected to a SLNC of the sciatic nerve and an ipsilateral intraganglionic MSC injection, using the von Frey and Choi tests. Control animals were subjected to the nerve lesion either alone or followed by the administration of phosphate-buffered saline (PBS) or bone marrow non-adherent mononuclear cells (BNMCs). All the animals were tested both before surgery and after 1, 3, 7, 14, 21, 28 and 56 days. Animals subjected to the sciatic nerve constriction developed ipsilateral mechanical and thermal allodynia already 3 days after the lesion. The allodynic responses were maintained even after 56 days. MSC administration prevented the generation of mechanical allodynia and reduced the number of allodynic responses to cold stimuli. On the contrary, the injection of either PBS or BNMCs could not counteract allodynia. These results suggest that MSCs may modulate pain generation after sciatic nerve constriction. The underlying mechanisms by which MSCs exert their actions on pain behavior need to be clarified.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Pain
dc.subject
Bone Marrow Transplantation
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Neuralgia
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Sciatic Nerve
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Stromal Cells
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Neurociencias
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Bone marrow stromal cells induce changes in pain behavior after sciatic nerve constriction
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-12T19:54:37Z
dc.identifier.eissn
1872-7972
dc.journal.volume
418
dc.journal.number
1
dc.journal.pagination
97-101
dc.journal.pais
Irlanda
dc.journal.ciudad
Limerick
dc.description.fil
Fil: Musolino, Patricia Leonor. Universidad Austral; Argentina
dc.description.fil
Fil: Coronel, Maria Florencia. Universidad Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Hökfelt, Tomas. Karolinska Institutet; Suecia
dc.description.fil
Fil: Villar, Marcelo José. Universidad Austral; Argentina
dc.journal.title
Neuroscience Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0304394007002704?via%3Dihub#!
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neulet.2007.03.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/17379405
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