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dc.contributor.author
Saravia, Flavia Eugenia
dc.contributor.author
Beauquis, Juan
dc.contributor.author
Pietranera, Luciana
dc.contributor.author
de Nicola, Alejandro Federico
dc.date.available
2017-11-03T00:46:28Z
dc.date.issued
2007-06
dc.identifier.citation
Saravia, Flavia Eugenia; Beauquis, Juan; Pietranera, Luciana; de Nicola, Alejandro Federico; Neuroprotective effects of estradiol in hippocampal neurons and glia of middle age mice.; Elsevier.; Psychoneuroendocrinology; 32; 5; 6-2007; 480-492
dc.identifier.issn
0306-4530
dc.identifier.uri
http://hdl.handle.net/11336/27517
dc.description.abstract
During aging the hippocampus experiences structural, molecular, and functional alterations. Protection from age-related disorders is provided by several factors, including estrogens. Since aging defects start at middle age, we studied if 17 beta-estradiol (E(2)) protected the hippocampus at this age period. Middle age (10-12 month old) male C57Bl/6 mice were implanted sc with E(2) (15 microg) or cholesterol pellets. Ten days afterwards they received bromodeoxyuridine (BrdU) 4 and 2h before killing to study cell proliferation in the dentate gyrus (DG). A pronounced depletion of BrdU+cells in the DG was found in cholesterol-treated middle age mice, accompanied by astrocytosis, and by neuronal loss in the hilus. Middle age mice receiving E(2) showed increased number of BrdU+cells while the other parameters were remarkably attenuated. When steroid treatment was prolonged for 2 months to study migration of cells in the granular layer of the DG, cell migration was unaffected by E(2). However, E(2)-treated middle age mice presented higher cell density and increased staining for doublecortin, a marker for differentiating neurons. Thus, from the three basic steps of adult neurogenesis (proliferation, migration, and differentiation), E(2) stimulated progenitor proliferation - even after long exposure to E(2) studied by Ki67 immunocytochemistry - and differentiation towards a neuronal lineage. This result, in conjunction with recovery from other aging indicators as increased deposits of the aging pigment lipofuscin in DG cells, loss of hilar neurons and astrocytosis supports a wide range protection of hippocampal function of middle age mice by estrogenic hormones.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Hipocampo
dc.subject
Estradiol
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Neuroproteccion
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Cell Death
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Hippocampus
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Neuroglia
dc.subject
Neuroprotective Agents
dc.subject.classification
Neurociencias
dc.subject.classification
Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Neuroprotective effects of estradiol in hippocampal neurons and glia of middle age mice.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-12T19:49:33Z
dc.identifier.eissn
1873-3360
dc.journal.volume
32
dc.journal.number
5
dc.journal.pagination
480-492
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.description.fil
Fil: Beauquis, Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Pietranera, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.description.fil
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.journal.title
Psychoneuroendocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.psyneuen-journal.com/article/S0306-4530(07)00056-X/fulltext
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.psyneuen.2007.02.012
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/17459595
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