Artículo
Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
Ahtiainen, Petteri; Rulli, Susana Beatriz
; Pakarainen, Tomi; Zhang, Fu-Ping; Poutanen, Matti; Huhtaniemi, Ilpo
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
01/2007
Editorial:
Elsevier Ireland
Revista:
Molecular and Cellular Endocrinology
ISSN:
0303-7207
e-ISSN:
1872-8057
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) alpha and beta subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function, but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic stimulus. The purpose of this review is to summarise the key findings on these two genetically modified mouse models.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Ahtiainen, Petteri; Rulli, Susana Beatriz; Pakarainen, Tomi; Zhang, Fu-Ping; Poutanen, Matti; et al.; Phenotypic characterisation of mice with exaggerated and missing LH/hCG action; Elsevier Ireland; Molecular and Cellular Endocrinology; 260-262; 1-2007; 255-263
Compartir
Altmétricas