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dc.contributor.author
Strik, Herwig M.
dc.contributor.author
Schmidt, Katharina
dc.contributor.author
Lingor, Paul
dc.contributor.author
Tonges, Lars
dc.contributor.author
Kugler, Wilfried
dc.contributor.author
Nitsche, Mirko
dc.contributor.author
Rabinovich, Gabriel Adrián
dc.contributor.author
Bähr, Mathias
dc.date.available
2017-11-02T22:51:35Z
dc.date.issued
2007-08
dc.identifier.citation
Strik, Herwig M.; Schmidt, Katharina; Lingor, Paul; Tonges, Lars; Kugler, Wilfried; et al.; Galectin-1 expression in human glioma cells: modulation by ionizing radiation and effects on tumor cell proliferation and migration; Spandidos Publ Ltd; Oncology Reports; 18; 2; 8-2007; 483-488
dc.identifier.issn
1021-335X
dc.identifier.uri
http://hdl.handle.net/11336/27506
dc.description.abstract
Galectins are evolutionarily conserved beta-galactoside-binding lectins which recognize specific glycoconjugates on the cell surface and the extracellular matrix. Accumulating evidence indicates that these proteins are involved in a variety of physiological and pathological processes including tumor growth and metastasis. Up-regulated expression of galectin-1 is a hallmark of a variety of malignant tumors. Here, we examined the expression of galectin-1 in glioma cell lines, the influence of ionizing irradiation and the intracellular and extracellular effects of this protein on tumor cell proliferation and migration. Galectin-1 was detected in both A172 and U118 glioma cells by immunoblot analysis. Ionizing irradiation induced a statistically significant up-regulation in glioma cell lines. RNA-interference-mediated silencing resulted in a significant suppression of the proliferation of the A172 cells, while the addition of recombinant galectin-1 had no effect. On the other hand, the migratory capacity of both cell lines was reduced after galectin-1 down-regulation, and up-regulated by the addition of exogenous galectin-1. Our results provide evidence of a role for galectin-1 in the regulation of glioma cell proliferation and migration. While an intracellular mechanism seemed to prevail in galectin-1-mediated regulation of tumor cell proliferation, the control of cell migration was exerted by both intracellular and extracellular mechanisms. In addition, this protein was up-regulated by ionizing radiation, indicating that the blockade of this protein should be performed before radiotherapy to avoid any undesired stimulating effects. Given the multifactorial role of galectin-1 in the regulation of tumor escape and metastasis, we conclude that targeting galectin-1 may have therapeutic benefits in the treatment of malignant glioma.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Spandidos Publ Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Galectin-1 expression in human glioma cells: modulation by ionizing radiation and effects on tumor cell proliferation and migration
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-12T19:48:40Z
dc.identifier.eissn
1791-2431
dc.journal.volume
18
dc.journal.number
2
dc.journal.pagination
483-488
dc.journal.pais
Grecia
dc.journal.ciudad
Atenas
dc.description.fil
Fil: Strik, Herwig M.. Universität Göttingen; Alemania
dc.description.fil
Fil: Schmidt, Katharina. Universität Göttingen; Alemania
dc.description.fil
Fil: Lingor, Paul. Universität Göttingen; Alemania
dc.description.fil
Fil: Tonges, Lars. Universität Göttingen; Alemania
dc.description.fil
Fil: Kugler, Wilfried. Universität Göttingen; Alemania
dc.description.fil
Fil: Nitsche, Mirko. Universität Göttingen; Alemania
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Bähr, Mathias. Universität Göttingen; Alemania
dc.journal.title
Oncology Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/or/18/2/483
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3892/or.18.2.483
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/17611674
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