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dc.contributor.author Rabinovich, Gabriel Adrián
dc.contributor.author Liu, F. T.
dc.contributor.author Hirashima, M.
dc.contributor.author Anderson, A.
dc.date.available 2017-11-02T22:45:16Z
dc.date.issued 2007
dc.identifier.citation Rabinovich, Gabriel Adrián; Liu, F. T.; Hirashima, M.; Anderson, A.; An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer; Blackwell Publishing; Scandinavian Journal Of Immunology; 66; 2-3; -1-2007; 143-158
dc.identifier.issn 0300-9475
dc.identifier.uri http://hdl.handle.net/11336/27505
dc.description.abstract Inflammation is a critical process for eliminating pathogens, but can lead to serious deleterious effects if left unchecked. Identifying the endogenous factors that control immune tolerance and inflammation is a key goal in the field of immunology. Galectins, a family of endogenous lectins with affinity for beta-galactoside-containing oligosaccharides, are expressed by several cells of the immune system and tissue-resident stromal cells. According to their architecture, this family of glycan-binding proteins is classified in those containing one-carbohydrate-recognition domain (CRD) (proto-type), those containing two-CRD joined by a linker non-lectin domain (tandem-repeat) and those that have one-CRD attached to an N-terminal peptide (chimera-type). Accumulating evidence indicates that galectins play critical regulatory roles in immune cell response and homeostasis. In this review, we summarize recent developments in our understanding of the galectins' roles within different immune cell compartments, and in the broader context of the inflammatory microenvironments. In particular we illustrate the immunoregulatory role of three representative members of each galectin subfamily: galectin-1, -3 and -9. This body of knowledge, documenting the coming of age of galectins as potential immunosuppressive agents or targets for anti-inflammatory drugs, represents a sound basis to further explore their potential as novel therapies for autoimmune diseases, chronic inflammation and cancer.
dc.format application/pdf
dc.language.iso eng
dc.publisher Blackwell Publishing
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject AUTOIMMUNE DISEASES
dc.subject GALECTINS
dc.subject INFLAMMATION MEDIATORS
dc.subject NEOPLASMS EXPERIMENTAL
dc.subject CANCER
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-10-12T19:48:37Z
dc.identifier.eissn 1365-3083
dc.journal.volume 66
dc.journal.number 2-3
dc.journal.pagination 143-158
dc.journal.pais Estados Unidos
dc.journal.ciudad Nueva Jersey
dc.description.fil Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil Fil: Liu, F. T.. University of California at Davis; Estados Unidos
dc.description.fil Fil: Hirashima, M.. University Kagawa; Japón
dc.description.fil Fil: Anderson, A.. Harvard Medical School; Estados Unidos
dc.journal.title Scandinavian Journal Of Immunology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2007.01986.x/abstract
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1365-3083.2007.01986.x
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/pmid/17635792


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)