Mostrar el registro sencillo del ítem

dc.contributor.author Silva Monteiro, Elizangela
dc.contributor.author Reis Lorenzato, Luciana
dc.contributor.author Kenji Nihei, Oscar
dc.contributor.author Junqueira, Mara
dc.contributor.author Rabinovich, Gabriel Adrián
dc.contributor.author Kaiyuan Hsu, Daniel
dc.contributor.author Liu, Fu Tong
dc.contributor.author Savino, Wilson
dc.contributor.author Chammas, Roger
dc.contributor.author Serra Villaverde, Dea Maria
dc.date.available 2017-11-02T22:39:53Z
dc.date.issued 2007
dc.identifier.citation Silva Monteiro, Elizangela; Reis Lorenzato, Luciana; Kenji Nihei, Oscar; Junqueira, Mara; Rabinovich, Gabriel Adrián; et al.; Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes during Trypanosoma cruzi infection; Amer Soc Investigative Pathology, Inc; American Journal Of Pathology; 170; 2; -1-2007; 546-556
dc.identifier.issn 0002-9440
dc.identifier.uri http://hdl.handle.net/11336/27503
dc.description.abstract During acute infection with Trypanosoma cruzi, the causative agent of Chagas´ disease, the thymus undergoes intense atrophy followed by a premature escape of CD4+CD8+ immature cortical thymocytes. Here we report a pivotal role for the endogenous lectin galectin-3 in accelerating death of thymocytes and migration of these cells away from the thymus after T. cruzi infection. We observed a pronounced increase in galectin-3 expression that paralleled the extensive depletion of CD4+CD8+ immature thymocytes after infection. In vitro, recombinant galectin-3 induced increased levels of death in cortical immature thymocytes. Consistent with the role of galectin-3 in promoting cell death, thymuses from gal-3-/- mice did not show cortical thymocyte depletion after parasite infection in vivo. In addition, galectin-3 accelerated laminin-driven CD4+CD8+ thymocyte migration in vitro and in vivo induced exportation of CD4+CD8+ cells from the thymus to the peripheral compartment. Our findings provide evidence of a novel role for galectin-3 in the regulation of thymus physiology and identify a potential mechanism based on protein-glycan interactions in thymic atrophy associated with acute T. cruzi infection
dc.format application/pdf
dc.language.iso eng
dc.publisher Amer Soc Investigative Pathology, Inc
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject CELL DEATH
dc.subject CHAGAS DISEASE
dc.subject GALECTIN-3
dc.subject THYMUS GLAND
dc.subject TRYPANOSOMA CRUZI
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification Patología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes during Trypanosoma cruzi infection
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-10-12T19:48:26Z
dc.identifier.eissn 1525-2191
dc.journal.volume 170
dc.journal.number 2
dc.journal.pagination 546-556
dc.journal.pais Estados Unidos
dc.journal.ciudad Filadelfia
dc.description.fil Fil: Silva Monteiro, Elizangela. Instituto Oswaldo Cruz; Brasil
dc.description.fil Fil: Reis Lorenzato, Luciana. Instituto Oswaldo Cruz; Brasil
dc.description.fil Fil: Kenji Nihei, Oscar. Instituto Oswaldo Cruz; Brasil
dc.description.fil Fil: Junqueira, Mara. Universidade de Sao Paulo; Brasil
dc.description.fil Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Kaiyuan Hsu, Daniel. University of California; Estados Unidos
dc.description.fil Fil: Liu, Fu Tong. University of California; Estados Unidos
dc.description.fil Fil: Savino, Wilson. Instituto Oswaldo Cruz; Brasil
dc.description.fil Fil: Chammas, Roger. Universidade de Sao Paulo; Brasil
dc.description.fil Fil: Serra Villaverde, Dea Maria. Instituto Oswaldo Cruz; Brasil
dc.journal.title American Journal Of Pathology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://ajp.amjpathol.org/article/S0002-9440(10)60878-4/abstract
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2353/ajpath.2007.060389
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851869/
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/pmid/17255323


Archivos asociados

Icon
Blocked Acceso no disponible

Aparece en la(s) siguiente(s) colección(ones)

  • Articulos(IBYME) [1027]
    Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)