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dc.contributor.author
Kouznetsov, Vladímir V.  
dc.contributor.author
Zacchino, Susana Alicia Stella  
dc.contributor.author
Sortino, Maximiliano Andrés  
dc.contributor.author
Vargas, Leonor Y.  
dc.contributor.author
Gupta, Mahabir P.  
dc.date.available
2025-10-30T11:41:20Z  
dc.date.issued
2012-10  
dc.identifier.citation
Kouznetsov, Vladímir V.; Zacchino, Susana Alicia Stella; Sortino, Maximiliano Andrés; Vargas, Leonor Y.; Gupta, Mahabir P.; Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives; Österreichische Apotheker‑Verlagsgesellschaft; Scientia Pharmaceutica; 80; 4; 10-2012; 867-877  
dc.identifier.issn
0036-8709  
dc.identifier.uri
http://hdl.handle.net/11336/274312  
dc.description.abstract
Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available a-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and á-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 µg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25-32 µg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Österreichische Apotheker‑Verlagsgesellschaft  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
A-Naphtylamines  
dc.subject
Antifungal properties  
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Cytotoxic agents  
dc.subject.classification
Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2025-10-29T10:49:02Z  
dc.identifier.eissn
2218-0532  
dc.journal.volume
80  
dc.journal.number
4  
dc.journal.pagination
867-877  
dc.journal.pais
Austria  
dc.journal.ciudad
Viena  
dc.description.fil
Fil: Kouznetsov, Vladímir V.. Universidad Industrial Santander; Colombia  
dc.description.fil
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina  
dc.description.fil
Fil: Sortino, Maximiliano Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina  
dc.description.fil
Fil: Vargas, Leonor Y.. Universidad Santo Tomás;  
dc.description.fil
Fil: Gupta, Mahabir P.. Universidad de Panamá; Panamá  
dc.journal.title
Scientia Pharmaceutica  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-0532/80/4/867  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3797/scipharm.1209-03  

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