Sauroine, an alkaloid from Huperzia saururus with activity in wistar rats in electrophysiological and behavioral assays related to memory retention

The present study describes the effects of sauroine (1), the main alkaloid obtained from Huperzia saururus, on memory retention and learning. To evaluate this, electrophysiological experiments and behavioral tests (step down) were performed on male Wistar rats. The results showed that 1 improved memory retention in the step-down test, significantly increasing hippocampal plasticity. Thus, 1 seems to be a constituent responsible for the activity claimed in folk medicine for H. saururus in Argentina.

Palabras clave: Huperzia Saururus , Sauroine , Memory Retention , Electrophysiological Assay

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/27310

URL: http://pubs.acs.org/doi/abs/10.1021/np800151v

DOI: http://dx.doi.org/10.1021/np800151v

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Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA

Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)

Citación

Vallejo, Mariana Guadalupe; Ortega, María Gabriela; Cabrera, Jose Luis; Carlini, Valeria Paola; Rubiales, Susana Elizabeth; et al.; Sauroine, an alkaloid from Huperzia saururus with activity in wistar rats in electrophysiological and behavioral assays related to memory retention; American Chemical Society; Journal of Natural Products; 72; 1; 12-2009; 156-158

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