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dc.contributor.author
Cárdenas, Paola A.
dc.contributor.author
Baena, Yolima
dc.contributor.author
Aragón, Diana M.
dc.contributor.author
Jimenez Kairuz, Alvaro Federico
dc.contributor.author
Martinez, Fleming
dc.date.available
2017-11-01T13:32:59Z
dc.date.issued
2013-04
dc.identifier.citation
Cárdenas, Paola A.; Baena, Yolima; Aragón, Diana M.; Jimenez Kairuz, Alvaro Federico; Martinez, Fleming; Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values; Colegio Farmaceuticos Provincia de Buenos Aires; Acta Farm. Bonaerense; 32; 6; 4-2013; 793-801
dc.identifier.issn
0326-2383
dc.identifier.uri
http://hdl.handle.net/11336/27297
dc.description.abstract
Based on van’t Hoff and Gibbs equations, thermodynamic functions Gibbs energy, enthalpy, and entropy of solution and mixing of 6-methylcoumarin in water at pH 1.2, 6.8, and 7.4, were evaluated from solubility values determined at five temperatures from 293.15 to 313.15 K. The solubility at all pH values was almost the same demonstrating a slight effect of pH on this physicochemical property. All the thermodynamic quantities of solution were positive indicating endothermic and entropy-driving dissolution processes at all pH values studied. The results were discussed in terms of solvent-solute and solventsolvent interactions, mainly hydrophobic hydration around non-polar groups of this drug.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Colegio Farmaceuticos Provincia de Buenos Aires
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
6-Methylcoumarin
dc.subject
Aqueous Solubility
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Solution Thermodynamics
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Ph
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-22T18:10:08Z
dc.journal.volume
32
dc.journal.number
6
dc.journal.pagination
793-801
dc.journal.pais
Argentina
dc.description.fil
Fil: Cárdenas, Paola A.. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Baena, Yolima. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Aragón, Diana M.. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Jimenez Kairuz, Alvaro Federico. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Martinez, Fleming. Universidad Nacional de Colombia; Colombia
dc.journal.title
Acta Farm. Bonaerense
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=32&num=6
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