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dc.contributor.author
Nina Estrella, Rose Emily
dc.contributor.author
Landa de Gargiulo, Adriana
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Lafuente, José Vicente
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Gargiulo, Pascual Angel
dc.date.available
2017-10-31T19:42:23Z
dc.date.issued
2014-04
dc.identifier.citation
Nina Estrella, Rose Emily; Landa de Gargiulo, Adriana; Lafuente, José Vicente; Gargiulo, Pascual Angel; Effects of antidepressants and soybean association in depressive menopausal women; Polskiego Towarzystwa Farmaceutycznego; Acta Poloniae Pharmaceutica; 71; 2; 4-2014; 323-327
dc.identifier.issn
0001-6837
dc.identifier.uri
http://hdl.handle.net/11336/27284
dc.description.abstract
Depression in menopausal women has been widely described for many years ago, and is related to hormonal decrease, mainly estrogens. The use of soy has been proposed as a possible coadjutant alternative to treat menopausal depressive disorder. In the present pilot clinical trial the effect of soybean, antidepressants and the association of soybean with antidepressants was studied in 40 depressive menopausal women for three months. Patients were divided in four groups of 10 women: fluoxetine (10 mg), soybean (100 mg), sertraline (50 mg), and sertraline (50 mg) plus soybean (100 mg). The Hamilton and Zung Depression Scales were used to measure the treatment effects. Values at the beginning and at the end of the study were compared. In all cases a significant difference was observed when the treated groups were compared vs. their untreated situation in both scales (p < 0.001). When a comparison between pre- minus post-treatment Zung scale scores was done,the effect induced by the association of sertraline and soybean was significantly higher than the other groups (p < 0.05). These effects were also seen using the Hamilton scale scores, showing significant differences between the association vs. soybean (p < 0.05) and setraline (p < 0.05) groups, but not vs. fluoxetine group. We conclude that soybean has an antidepressant effect per se, and the association of soybean and antidepressants increases their effects.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Polskiego Towarzystwa Farmaceutycznego
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Menopause
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Depressive Disorder
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Soybean
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Antidepressant
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Serotonin Selective Reuptake Inhibitor
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Reumatología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effects of antidepressants and soybean association in depressive menopausal women
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-26T18:58:40Z
dc.journal.volume
71
dc.journal.number
2
dc.journal.pagination
323-327
dc.journal.pais
Polonia
dc.journal.ciudad
Varsovia
dc.description.fil
Fil: Nina Estrella, Rose Emily. Universidad Autónoma de Santo Domingo. Faculty of Health Science. School of Physiological Sciences; República Dominicana
dc.description.fil
Fil: Landa de Gargiulo, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Lafuente, José Vicente. Universidad del Pais Vasco. Departamento de Neurociencia. Laboratorio de Neurociencia Experimental; España. Universidad Autónoma de Chile. Facultad de Ciencias de la Salud; Chile
dc.description.fil
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Acta Poloniae Pharmaceutica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ptfarm.pl/pub/File/Acta_Poloniae/2014/2/323.pdf
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