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dc.contributor.author
Kenney, Jessica
dc.contributor.author
Rodríguez, Aixa
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Kizima, Larisa
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Seidor, Samantha
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Menon, Radhika
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Jean Pierre, Ninochka
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Pugach, Pavel
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Levendosky, Keith
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Derby, Nina
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Gettie, Agegnehu
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Blanchard, James
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Piatak, Michael
dc.contributor.author
Lifson, Jeffrey D.
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Paglini, Maria Gabriela
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Zydowsky, Thomas M.
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Robbiani, Melissa
dc.contributor.author
Fernández Romero, José A.
dc.date.available
2017-10-31T14:50:10Z
dc.date.issued
2013-06
dc.identifier.citation
Kenney, Jessica; Rodríguez, Aixa; Kizima, Larisa; Seidor, Samantha; Menon, Radhika; et al.; A Modified Zinc Acetate Gel, a Potential Nonantiretroviral Microbicide, Is Safe and Effective against Simian-Human Immunodeficiency Virus and Herpes Simplex Virus 2 Infection In Vivo; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 57; 8; 6-2013; 4001-4009
dc.identifier.issn
0066-4804
dc.identifier.uri
http://hdl.handle.net/11336/27229
dc.description.abstract
We previously showed that a prototype gel comprising zinc acetate (ZA) in carrageenan (CG) protected mice against vaginal and rectal herpes simplex virus 2 (HSV-2) challenge as well as macaques against vaginal simian-human immunodeficiency virus reverse transcriptase (SHIV-RT) challenge. In this work, we modified buffers and cosolvents to obtain a stable, nearly iso-osmolal formulation and evaluated its safety and efficacy against SHIV-RT and HSV-2. In vitro toxicity to lactobacilli and Candida albicans was determined. Macaques were given daily doses of ZA and CG (ZA/CG) or CG alone vaginally for 14 days and challenged with SHIV-RT 24 h later. Mice were challenged vaginally or rectally with HSV-2 immediately after a single gel treatment to measure efficacy or vaginally 12 h after daily gel treatment for 7 days to evaluate the gel's impact on susceptibility to HSV-2 infection. The modified ZA/CG neither affected the viability of lactobacilli or C. albicans nor enhanced vaginal HSV-2 infection after daily ZA/CG treatment. Vaginal SHIV-RT infection of macaques was reduced by 66% (P = 0.006) when macaques were challenged 24 h after the last dose of gel. We observed 60% to 80% uninfected mice after vaginal (P < 0.0001) and rectal (P = 0.008) high-dose HSV-2 challenge. The modified ZA/CG gel is safe and effective in animal models and represents a potential candidate to limit the transmission of HIV and HSV-2.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Microbiology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Microbicides
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Zinc Acetate
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Macaques
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Shiv-Rt
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Hsv-2
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Mouse
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Vaginal
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Rectal
dc.subject.classification
Ética Médica
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
A Modified Zinc Acetate Gel, a Potential Nonantiretroviral Microbicide, Is Safe and Effective against Simian-Human Immunodeficiency Virus and Herpes Simplex Virus 2 Infection In Vivo
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-02T19:06:34Z
dc.journal.volume
57
dc.journal.number
8
dc.journal.pagination
4001-4009
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Washington DC
dc.description.fil
Fil: Kenney, Jessica. Center for Biomedical Research; Estados Unidos
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Fil: Rodríguez, Aixa. Center for Biomedical Research; Estados Unidos
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Fil: Kizima, Larisa. Center for Biomedical Research; Estados Unidos
dc.description.fil
Fil: Seidor, Samantha. Center for Biomedical Research; Estados Unidos
dc.description.fil
Fil: Menon, Radhika. Center for Biomedical Research; Estados Unidos
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Fil: Jean Pierre, Ninochka. Center for Biomedical Research; Estados Unidos
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Fil: Pugach, Pavel. Center for Biomedical Research; Estados Unidos
dc.description.fil
Fil: Levendosky, Keith. Center for Biomedical Research; Estados Unidos
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Fil: Derby, Nina. Center for Biomedical Research; Estados Unidos
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Fil: Gettie, Agegnehu. The Rockefeller University; Estados Unidos
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Fil: Blanchard, James. University of Tulane; Estados Unidos
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Fil: Piatak, Michael. Frederick National Laboratory for Cancer Research; Estados Unidos
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Fil: Lifson, Jeffrey D.. Frederick National Laboratory for Cancer Research; Estados Unidos
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Fil: Paglini, Maria Gabriela. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina
dc.description.fil
Fil: Zydowsky, Thomas M.. Center for Biomedical Research; Estados Unidos
dc.description.fil
Fil: Robbiani, Melissa. Center for Biomedical Research; Estados Unidos
dc.description.fil
Fil: Fernández Romero, José A.. Center for Biomedical Research; Estados Unidos. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina
dc.journal.title
Antimicrobial Agents and Chemotherapy
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/AAC.00796-13
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/57/8/4001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719770/
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