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dc.contributor.author
Fina, Brenda Lorena  
dc.contributor.author
Brance, María Lorena  
dc.contributor.author
Brun, Lucas Ricardo Martín  
dc.contributor.author
Rigalli, Alfredo  
dc.date.available
2025-09-17T11:51:56Z  
dc.date.issued
2012-12  
dc.identifier.citation
Fina, Brenda Lorena; Brance, María Lorena; Brun, Lucas Ricardo Martín; Rigalli, Alfredo; Fluoride inhibition of oxygen consumption and increased oxidative stress in rats; International Society for Fluoride Research; Fluoride; 45; 4; 12-2012; 343-348  
dc.identifier.issn
0015-4725  
dc.identifier.uri
http://hdl.handle.net/11336/271231  
dc.description.abstract
The aim of this work was to evaluate the effect of fluoride (F) on oxygen consumption (VO2) in rats and how it might affect the respiratory chain and the levels of reactive oxygen species (ROS). Eighteen Sprague-Dawley rats were divided into three groups: Control, NaF20, and NaF40,which received 0, 20, and 40 µmol F/100 g bw/day for 30 days, respectively. In vivo, VO2 decreased 90 min after treatment with F, whereas TBARS, CAT, and GPx were higher. In vitro, F decreased VO2in liver and in mitochondria. These results support the hypothesis that the bone inflammatory foci observed in treatments with NaF could involve an inhibition of the respiratory chain that would cause increase in reactive oxygen species (ROS).  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
International Society for Fluoride Research  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
LIVER  
dc.subject
FLUORIDE AND OXYGEN IN RATS  
dc.subject
MITOCHONDRIA  
dc.subject
OXIDATIVE STRESS  
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RAT OXYGEN CONSUMPTION  
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REACTIVE OXYGEN SPECIES  
dc.subject.classification
Farmacología y Farmacia  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Fluoride inhibition of oxygen consumption and increased oxidative stress in rats  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2025-09-03T12:44:51Z  
dc.journal.volume
45  
dc.journal.number
4  
dc.journal.pagination
343-348  
dc.journal.pais
Nueva Zelanda  
dc.journal.ciudad
Dunedin  
dc.description.fil
Fil: Fina, Brenda Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina  
dc.description.fil
Fil: Brance, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina  
dc.description.fil
Fil: Brun, Lucas Ricardo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina  
dc.description.fil
Fil: Rigalli, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina  
dc.journal.title
Fluoride  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.fluorideresearch.org/454/files/FJ2012_v45_n4_p343-348_sfs.pdf  

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