Densitometric measurement of 18O content of 18O-enriched water in relation to the production of 18F-labelled radiopharmaceuticals

Abstract

The densities of mixtures of ordinary water and 18O enriched water have been measured all over the range of compositions, at temperatures between 293.15 and 313.15 K, using a vibrating-tube densitometer. From the error analysis of the density data in the 18O enriched water region (atom % 18O > 95) we concluded that densitometry measurements with an accuracy of ±0.00002 g cm− 3 , provide a simple, precise and low-cost method to determine the 18O enrichment degree of recycled heavy oxygen water used to generate radiopharmaceuticals, such as [ 18F]fluoro-2-deoxy-D-glucose for the Positron-Emission Tomography (PET) scanning.