Comparative body mass index effect on total and undercarboxilated osteocalcina between normoglucemic premenopausal women and men

Abstract

We found that body mass index (BMI) through leptin affected osteocalcin (OCN), which in turn influences insulin and glucose homeostasis in men. Now we evaluated such effect in 35 premenopausal women (PMW) comparing the results obtained in these 45 men. All subjects were non-diabetic having normal glucose and HbA1c and were divided according to BMI index in overweight (OW) or type I, II, III obesity (OB) degree. Glucose, HbA1c were measured by standard methods; undercarboxilated OCN (ucOCN) (ng/mL), total OCN (ng/mL), leptin (ng/mL), insulin (uUI/L) and CTX (ng/L) by ELISA, and 25hydroxyvitaminD (25OHD) (ng/mL) by a competitive protein-binding method. Results (mean±SD): In both genders, ucOCN increased and OCN decreased with BMI increase (P<0.01) although with some differences by sex: women between OBTIII and the remaining groups (P<0.01); men; ucOCN in OW vs. the three OB types and OCN from OW to OBTIII (p<0.01). In both genders, leptin increased with BMI increase (p<0.01) while insulin increased in OBTII and OBTIII vs. OW and OB TI (p<0.05); the lowest 25OHD was observed in TIII obesity.Results suggested that BMI effect on ucOCN and OCN present some differences between women and men; although in both genders OCN changes appears to influence insulin levels and glucose homeostasis.