Reverse micelles: A versatile platform for the generation of highly controlled polymeric nanoparticles

Abstract

The generation of polymeric nanoparticles (NPs) with specific properties has become a highly significant area of scientific and technological research. Reverse micelles (RMs) have emerged as a versatile platform to achieve this goal. These supramolecular aggregates are formed by the self-assembly of surfactants in nonpolar media, where the nonpolar segments of the surfactants orient toward the organic solvent, while the polar segments point inward, forming a polar core. This organization creates confined spaces where polymers can be synthesized, packed, and stabilized. The key advantage of RMs lies in their ability to precisely control the formation of polymeric NPs, owing to the strong interactions within the system. By modifying the water content, surfactant structure, and the types of polymers used, the composition and size of the NPs can be finely tuned. Additionally, RMs enable the incorporation of various compounds, such as drugs or proteins, into the polymeric NPs. Their compatibility with a wide range of polymers further enhances their versatility and applicability across diverse chemical and biological environments. In conclusion, RMs represent a promising and adaptable platform for generating highly controlled polymeric NPs, offering significant potential in numerous scientific and technological applications.