Mostrar el registro sencillo del ítem

dc.contributor.author
Roewer, Lutz
dc.contributor.author
Nothnagel, Michael
dc.contributor.author
Gusmão, Leonor
dc.contributor.author
Gomes, Verónica
dc.contributor.author
Miguel González
dc.contributor.author
Corach, Daniel
dc.contributor.author
Sala, Adriana Andrea
dc.contributor.author
Alechine, Evguenia
dc.contributor.author
Palha, Teresinha
dc.contributor.author
Santos, Ney
dc.contributor.author
dos Santos, Andrea Ribeiro
dc.contributor.author
Geppert, Maria
dc.contributor.author
Willuweit, Sascha
dc.contributor.author
Zweynert, Sarah
dc.contributor.author
Baeta, Miriam
dc.contributor.author
Núñez, Carolina
dc.contributor.author
Martínez Jarreta, Begoña
dc.contributor.author
González Andrade, Fabricio
dc.contributor.author
de Carvalho, Elizeu Fagundes
dc.contributor.author
da Silva, Dayse Aparecida
dc.contributor.author
Builes,Juan José
dc.contributor.author
Turbón, Daniel
dc.contributor.author
Lopez Parra, Ana Maria
dc.contributor.author
Arroyo Pardo, Eduardo
dc.contributor.author
Toscanini, Ulises
dc.contributor.author
Borjas, Lisbeth
dc.contributor.author
Barletta, Claudia
dc.contributor.author
Ewart, Elizabeth
dc.contributor.author
Santos, Sidney
dc.contributor.author
Krawczak, Michael
dc.date.available
2017-10-18T20:33:11Z
dc.date.issued
2013-04
dc.identifier.citation
Roewer, Lutz; Nothnagel, Michael; Gusmão, Leonor; Gomes, Verónica; Miguel González; et al.; Continent-wide decoupling of Y-chromosomal genetic variation from language and geography in native South Americans; Public Library Science; Plos Genetics; 9; 4; 4-2013; 1-16; e1003460
dc.identifier.issn
1553-7390
dc.identifier.uri
http://hdl.handle.net/11336/26787
dc.description.abstract
Numerous studies of human populations in Europe and Asia have revealed a concordance between their extant genetic structure and the prevailing regional pattern of geography and language. For native South Americans, however, such evidence has been lacking so far. Therefore, we examined the relationship between Y-chromosomal genotype on the one hand, and male geographic origin and linguistic affiliation on the other, in the largest study of South American natives to date in terms of sampled individuals and populations. A total of 1,011 individuals, representing 50 tribal populations from 81 settlements, were genotyped for up to 17 short tandem repeat (STR) markers and 16 single nucleotide polymorphisms (Y-SNPs), the latter resolving phylogenetic lineages Q and C. Virtually no structure became apparent for the extant Y-chromosomal genetic variation of South American males that could sensibly be related to their inter-tribal geographic and linguistic relationships. This continent-wide decoupling is consistent with a rapid peopling of the continent followed by long periods of isolation in small groups. Furthermore, for the first time, we identified a distinct geographical cluster of Y-SNP lineages C-M217 (C3*) in South America. Such haplotypes are virtually absent from North and Central America, but occur at high frequency in Asia. Together with the locally confined Y-STR autocorrelation observed in our study as a whole, the available data therefore suggest a late introduction of C3* into South America no more than 6,000 years ago, perhaps via coastal or trans-Pacific routes. Extensive simulations revealed that the observed lack of haplogroup C3* among extant North and Central American natives is only compatible with low levels of migration between the ancestor populations of C3* carriers and non-carriers. In summary, our data highlight the fact that a pronounced correlation between genetic and geographic/cultural structure can only be expected under very specific conditions, most of which are likely not to have been met by the ancestors of native South Americans.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Y Strs
dc.subject
American Continent
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Continent-wide decoupling of Y-chromosomal genetic variation from language and geography in native South Americans
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2015-05-27T18:05:13Z
dc.journal.volume
9
dc.journal.number
4
dc.journal.pagination
1-16; e1003460
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Roewer, Lutz. Charité – Universtätsmedizin; Alemania
dc.description.fil
Fil: Nothnagel, Michael. Universitat Zu Köln; Alemania. Christian-Albrechts-Universität; Alemania
dc.description.fil
Fil: Gusmão, Leonor. Universidad de Porto; Portugal. Universidade Federal do Pará; Brasil
dc.description.fil
Fil: Gomes, Verónica. Universidad de Porto; Portugal
dc.description.fil
Fil: Miguel González. Universidad de Porto; Portugal
dc.description.fil
Fil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sala, Adriana Andrea. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Alechine, Evguenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Palha, Teresinha. Centro de Investigaciones Filosóficas; Argentina. Universidade Federal do Pará; Brasil
dc.description.fil
Fil: Santos, Ney. Universidade Federal do Pará; Brasil
dc.description.fil
Fil: dos Santos, Andrea Ribeiro. Universidade Federal do Pará; Brasil
dc.description.fil
Fil: Geppert, Maria. Charité-Universtätsmedizin; Alemania
dc.description.fil
Fil: Willuweit, Sascha. Charité-Universtätsmedizin; Alemania
dc.description.fil
Fil: Zweynert, Sarah. Charité-Universtätsmedizin; Alemania
dc.description.fil
Fil: Baeta, Miriam. Universidad de Zaragoza; España
dc.description.fil
Fil: Núñez, Carolina. Universidad de Zaragoza; España
dc.description.fil
Fil: Martínez Jarreta, Begoña. Universidad de Zaragoza; España
dc.description.fil
Fil: González Andrade, Fabricio. Ministerio de Salud Pública. Departamento de Ciencia y Tecnología; Ecuador
dc.description.fil
Fil: de Carvalho, Elizeu Fagundes. Universidade do Estado do Rio de Janeiro. Instituto de Biologia, Laboratorio de Diagnósticos por DNA; Brasil
dc.description.fil
Fil: da Silva, Dayse Aparecida. Universidade do Estado do Rio de Janeiro. Instituto de Biologia, Laboratorio de Diagnósticos por DNA; Brasil
dc.description.fil
Fil: Builes,Juan José. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Turbón, Daniel. Universidad de Barcelona; España
dc.description.fil
Fil: Lopez Parra, Ana Maria. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Arroyo Pardo, Eduardo. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Toscanini, Ulises. Fundación Favaloro; Argentina
dc.description.fil
Fil: Borjas, Lisbeth. Universidad del Zulia; Venezuela
dc.description.fil
Fil: Barletta, Claudia. Universidad Nacional Mayor de San Marcos; Perú
dc.description.fil
Fil: Ewart, Elizabeth. University of Oxford; Reino Unido
dc.description.fil
Fil: Santos, Sidney. Universidade Federal do Pará; Brasil
dc.description.fil
Fil: Krawczak, Michael. Christian-Albrechts-Universität; Alemania
dc.journal.title
Plos Genetics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003460
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pgen.1003460