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Artículo

Endocannabinoid regulation in the cervix during pregnancy: insights into molecular mechanisms of premature labor

Marvaldi, CarolinaIcon ; Herrero, Felisa; Johnson, Clare; Schander, Julieta AylenIcon ; Correa, Fernando GabrielIcon ; Cella, MaximilianoIcon ; Aisemberg, JulietaIcon ; Franchi, Ana MariaIcon ; Bradshaw, Heather; Wolfson, Manuel LuisIcon
Fecha de publicación: 01/2024
Editorial: BioScientifica
Revista: Reproduction
ISSN: 1470-1626
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

During pregnancy, the main role of the cervix is to isolate the fetus from outside pathogens and maintain the relatively closed system of uterine gestation. Conversely, towards the end of pregnancy, the cervix must be remodeled to increase flexibility and allow the delivery. This process is called cervical remodeling and dysregulation of the process plays a role in premature delivery. The endocannabinoidome plays an important role in several reproductive events, however its function on cervical tissue throughout pregnancy is poorly understood. The goal of this study was to evaluate the presence and participation of the endocannabinoidome in lipopolysaccharide (LPS)-induced cervical changes. Therefore, we evaluated key components of the endocannabinoidome in cervical tissue from non-pregnant mice and pregnant mice with and without LPS treatment. Using mass spectrometric analysis, we found an increase in anandamide and 2-arachidonoylglycerol in the cervix of pregnant mice when compared to non-pregnant mice. We have also found a reduction in FAAH protein expression in these tissues. Furthermore, when treated with LPS, we observed a reduction in the cervical immunostaining with anti-CB1, and anti-CB2 antibodies. Likewise, using cervix explants from pregnant mice, we found that LPS significantly increased cervical metalloprotease activity and cyclooxygenase 2, which were subsequently modulated by cannabinoid receptor antagonists. Collectively, our findings suggest that an LPS-induced imbalance of cervix endocannabinoidome likely contributes to premature cervical remodeling, which is part of the key components that contribute to premature delivery.
Palabras clave: ENDOCANNABINOID , PREGNANCY , CERVIX , PREMATURE LABOR
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/265926
URL: https://rep.bioscientifica.com/view/journals/rep/aop/rep-23-0383/rep-23-0383.xml
DOI: http://dx.doi.org/10.1530/REP-23-0383
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Marvaldi, Carolina; Herrero, Felisa; Johnson, Clare; Schander, Julieta Aylen; Correa, Fernando Gabriel; et al.; Endocannabinoid regulation in the cervix during pregnancy: insights into molecular mechanisms of premature labor; BioScientifica; Reproduction; 167; 4; 1-2024; 1-12
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