Design of Cannabis sativa (L.) Emulsion: Characterization and Quantification of Cannabinoids and Terpenes

Abstract

The aim of this study was to design and develop emulsions with cannabidiol-rich ethanolic extract (EE) and essential oil (EO) of Cannabis sativa L. as active and coactive herbal ingredients respectively. At the same time, an analytical methodology was developed to quantify the main cannabinoids and characterize the terpenes of the essential oil. Four O/W emulsions were prepared with 1% of EE (1g EE/100 g emulsion) F1, 0.5 % of EE (0.5g EE/100 g emulsion) F2, 0.25 % of EE (0.25g EE/100 g emulsion) F3 and 0.125 % of EE (0.125 g EE/100 g emulsion) F4. The co-active ingredient (EO) was added following the same proportions as the EE. All emulsions, F1, F2, F3, y F4 were found to have acceptable physicochemical characteristics such as pH, viscosity, extensibility, stability. Respect to the organoleptic properties only F1 was no acceptable.