Safe in pregnancy: A global living systematic review and meta-analysis of COVID-19 vaccines in pregnancy

Abstract

Pregnant persons are a high priority-use group for COVID-19 vaccination, given their higher risk of maternal and perinatal complications and death following COVID-19 infections in pregnancy [1], [2]. However, global coverage of COVID-19 vaccines in pregnancy remains low and several countries still do not recommend the vaccines in pregnancy [3], [4]. One of the challenges for policymakers and clinicians is access to the rapidly growing literature on COVID-19 vaccines in a user-friendly, synthesized format from trustworthy sources. Living systematic reviews continuously update the relevant literature, incorporating new evidence as it becomes available and making the evidence more accessible to decision makers. We are conducting a living systematic review and meta-analysis of COVID-19 vaccines in pregnancy, which assesses vaccine safety, immunogenicity, efficacy and effectiveness in pregnant persons and their infants (PROSPERO ID = CRD42021281290) via an interactive online database (https://www.safeinpregnancy.org/living-systematic-review/) [5], [6]. This project is supported by a diverse, expert Scientific and Technical Advisory Group (STAG) [6]. We presently report data on more than half a million vaccinated pregnant persons across 26 countries. The database is updated every two weeks to provide rapid access to up-to-date information...